Study to Validate a Computerized Neuropsychological Test Battery
|ClinicalTrials.gov Identifier: NCT01421446|
Recruitment Status : Terminated (Insufficient subject recruitment)
First Posted : August 22, 2011
Last Update Posted : April 1, 2015
|Condition or disease|
Cognitive decline is one of the primary symptom triad of Normal Pressure Hydrocephalus (NPH). Neuropsychological measures have been demonstrated as being effective in the diagnosis of NPH, and in assessing the efficacy of treatment intervention. Hence, neuropsychological assessment is a critical component in the assessment for the presence of NPH. Specifically, measures of attention/concentration, fine motor skills, executive functioning abilities, speed of processing and memory have been found to be useful in the assessment of NPH and treatments thereof.
Neuropsychologists are typically found in large hospitals, academic centers and in urban locations. Neuropsychologists are under represented in rural or low population centers. At the present time, cognitive assessment is frequently limited to a Mini Mental Status Examination. Furthermore, neuropsychological testing can be very expensive for patients, given insurance constraints. Finally, there is no standardized test battery that is used in different centers treating this patient population. The creation of a standard battery that could be used in other NPH centers would promote research collaboration.
A computerized neuropsychological test battery was developed in Umea, Sweden with the specific goal of using tests that are considered to be sensitive to the cognitive profile observed in NPH. The battery was developed in JAVA and Adobe Flash making it platform independent (Runs on Mac, Windows and Linux). The test battery is administered on a touch screen display, where the tests are presented through animations with audio instructions. Before the real test trails are administered, subjects are given practice trials with auditory and visual feedback. For the American version of the test, the auditory stimuli have been translated and recorded in English.
|Study Type :||Observational|
|Actual Enrollment :||1 participants|
|Official Title:||Reliability and Validity of Umea Computerized Neuropsychological Battery|
|Study Start Date :||September 2011|
|Actual Primary Completion Date :||September 2013|
|Actual Study Completion Date :||December 2013|
- Computer Hydrocephalus Neuropsychological Assessment Versions 1 & 2 [ Time Frame: Within 2-5 weeks of enrollment ]
- Standard Hydrocephalus Neuropsychological Assessment: Versions 1 & 2 [ Time Frame: Within 2-5 weeks of enrollment ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01421446
|United States, Maryland|
|Sandra and Malcolm Berman Brain & Spine Institute|
|Baltimore, Maryland, United States, 21209|
|Principal Investigator:||Michael A Williams, MD||LifeBridge Health|