Alzheimer's Disease Core Center (ADCC)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01421420 |
Recruitment Status :
Recruiting
First Posted : August 22, 2011
Last Update Posted : June 12, 2015
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The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening.
All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.
Condition or disease |
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Alzheimer's Disease Mild Cognitive Impairment Age-Related Memory Disorders |
Study Type : | Observational |
Estimated Enrollment : | 900 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Arizona Alzheimer's Disease Core Center |
Study Start Date : | July 2001 |
Estimated Primary Completion Date : | December 2024 |
Estimated Study Completion Date : | July 2025 |

Group/Cohort |
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Alzheimer's Disease |
Mild Cognitive Impairment |
Other forms of Dementia, not AD |
Normal Elderly Individuals |
- Neuropsychological Test Scores [ Time Frame: Up to 20 years ]Cognitive function will be evaluated on a yearly basis using a battery of neuropsychological tests, which will then be scored and normed according to established guidelines.
- Neurological Exam [ Time Frame: Up to 20 Years ]A thorough neurological exam will be performed once per year to evaluate neurological function.
- Brain Tissue [ Time Frame: From date of entry until date of death assessed up to 20 years ]A brain autopsy will be performed upon the participant's death to establish histological diagnosis.
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 50 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
For patients with MCI, or dementia, the presence of cognitive deficits including memory, language, and executive function.
Exclusion Criteria:
Presence of non-neurological medical conditions interfering with cognition.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01421420
United States, Arizona | |
University of Arizona, University Medical Center | Recruiting |
Tucson, Arizona, United States, 85724 | |
Contact: Kim Corley, B.A. 520-626-3746 kgcorley@email.arizona.edu | |
Principal Investigator: Steven Z Rapcsak, M.D. |
Principal Investigator: | Steven Z Rapcsak, M.D. | University of Arizona |
Responsible Party: | University of Arizona |
ClinicalTrials.gov Identifier: | NCT01421420 |
Other Study ID Numbers: |
P30AG019610 ( U.S. NIH Grant/Contract ) P30AG019610 ( U.S. NIH Grant/Contract ) |
First Posted: | August 22, 2011 Key Record Dates |
Last Update Posted: | June 12, 2015 |
Last Verified: | January 2015 |
Alzheimer's Dementia Mild Cognitive Impairment |
Alzheimer Disease Memory Disorders Cognitive Dysfunction Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases |
Tauopathies Neurodegenerative Diseases Neurocognitive Disorders Mental Disorders Cognition Disorders Neurobehavioral Manifestations Neurologic Manifestations |