Systemic Effects of Epidural Methylprednisolone Injection on Glucose Tolerance in Diabetic Patients

This study has been completed.
Information provided by (Responsible Party):
zufferey Pascal, Centre Hospitalier Universitaire Vaudois Identifier:
First received: August 18, 2011
Last updated: NA
Last verified: August 2011
History: No changes posted
Several studies have shown that in diabetic patients, the glycemic profile was disturbed after intra-articular injection of corticosteroids. Little is known about the impact of epidural injection in such patients. The goal of this study was double, at first comparing the glycaemic profile in diabetic patients after a unique injection of 80 mg of acetate methylprednisolone either intra-articular or epidural, secondly to compare the amount of systemic diffusion of the drug the after both procedures.

Condition Intervention
Drug: intra-articular infiltration
Drug: epidural infiltration

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Pharmacokinetics/Dynamics Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention

Resource links provided by NLM:

Further study details as provided by Centre Hospitalier Universitaire Vaudois:

Primary Outcome Measures:
  • glycemic values, [ Time Frame: day 0 to day 15 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • urinary excretion rate [ Time Frame: day 0 to day 15 ] [ Designated as safety issue: No ]

Enrollment: 25
Study Start Date: August 2008
Study Completion Date: June 2010
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: methylprednisolone,infiltration Drug: intra-articular infiltration
intra articular infiltration
Active Comparator: epidural injection Drug: epidural infiltration
epidural infiltration


Ages Eligible for Study:   20 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • diabetes stable for more than ten days
  • no contraindication for steroids
  • lumbar stenosis
  • articular pain

Exclusion Criteria:

  • unstable diabetes
  • renal insufficiency
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Please refer to this study by its identifier: NCT01420497

Lausanne, VD, Switzerland, 1001
Sponsors and Collaborators
Centre Hospitalier Universitaire Vaudois
  More Information

No publications provided

Responsible Party: zufferey Pascal, md, Centre Hospitalier Universitaire Vaudois Identifier: NCT01420497     History of Changes
Other Study ID Numbers: gylperi 
Study First Received: August 18, 2011
Last Updated: August 18, 2011
Health Authority: swissmedic: Switzerland

Keywords provided by Centre Hospitalier Universitaire Vaudois:
intra articular infiltration
epidural infiltration

Additional relevant MeSH terms:
Methylprednisolone Hemisuccinate
Methylprednisolone acetate
Prednisolone acetate
Prednisolone hemisuccinate
Prednisolone phosphate
Anti-Inflammatory Agents
Antineoplastic Agents
Antineoplastic Agents, Hormonal
Autonomic Agents
Central Nervous System Agents
Gastrointestinal Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Neuroprotective Agents
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Protective Agents
Therapeutic Uses processed this record on February 10, 2016