Comparison of Soy-milk and Cow Milk Consumption on Inflammatory Factors, Cardiovascular Factors ,Renal Factors, Fibrinolytic Indice and Oxidative Stress Among Type-2 Diabetic Patients With Nephropathy Stage 1 and 2
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Soymilk components such as isoflavones, essential fatty acids, phytoesterols, good fats, inositols might have beneficial effects on controlling complication among diabetic nephropathy patients(DN).Most studies in this regard have been examined the effect of soy consumption on cardiorenal risk factors among patients with DN and there are few data about relationship of soy milk consumption and health effect in patients with DN . Therefore, we evaluated the effects of soy milk compared to cow's milk on blood pressure, inflammation, oxidative stress and fibrinolytic markers and cardiorenal risk factors among these patients. This was a cross-over randomized clinical trial which was conducted in Isfahan among diabetic nephropathy patients. Patients were randomly assigned to consume a diet containing cow's milk or a diet in which only one glass of soy milk was substituted; each one for 4 weeks.
Condition or disease
InflammationOxidative StressFibrinolytic MarkersBlood Pressure and Cardiorenal Risk Factors
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Ages Eligible for Study:
28 Years to 81 Years (Adult, Senior)
Sexes Eligible for Study:
adults with (>18y old) diagnosis of type 2 diabetics nephropathy (diabetics subjects that had proteinuria more than 300 mg/day and had GFR more than 90 mL/min )
exclusion criteria included diabetic nephropathy patients that they were pregnant or lactation women
changing dosage of oral hypoglycemic agents
use of hormone replacement therapy
alcohol and cigarette consumption;allergy or intolerance to soybeans or milk
presence of breast malignant and avoid of advisory diet