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Effects of Unilateral WBV on Muscleactivity of Contralateral Hip Adductor (WBV-BM)

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ClinicalTrials.gov Identifier: NCT01419782
Recruitment Status : Completed
First Posted : August 18, 2011
Last Update Posted : May 7, 2013
Information provided by (Responsible Party):

Study Description
Brief Summary:

The aim of this study is to investigate effects of femur exposed to unilateral vibration on the rest muscle electrical activity of contralateral hip adductors and contralateral soleus H-reflex in young adult men.

This study hypothesize that femur exposed to unilateral vibration may affect the rest muscle electrical activity of contralateral hip adductors. Vibration can effectively enhance muscle strength and power. Previous studies have shown that vibration increases muscle electromyographic (EMG) activity. It has been showed that bone has an effect on the increase in muscle EMG activity caused by vibration in healthy young adults in a study. In this study, it was reported that vibrations-induced increases in muscle electrical activity of flexor carpi radialis (FCR) was related to ultradistal radius bone mineral content (BMC) and the FCR H-reflex was suppressed or depressed during vibration. This findings were reported to support the assumption that the bone exposed to cyclic mechanical loading may neuronally regulate muscle activity.

Condition or disease Intervention/treatment
Bone Mass Effects of Vibration Other: Whole-body vibration

Detailed Description:

A total of 20 voluntaries are planned to include in this study.

Vibration will be applied the right lower extremity by whole-body vibration (PowerPlate Pro). Cases will stand on vibration plate. WBV will be applied at a frequency of 40 Hz and amplitude of 2 mm for 60 seconds. WBV will be applied one session only.

The rest muscle electrical activity of ipsilateral and contralateral hip adductor muscles at rest will be measured by PowerLab (data acquisition system, ADInstruments, Australia) device.The rest-EMGrms will be measured at before and during vibration. We also evaluate a change in contralateral soleus H reflex during vibration.

Effects of bone on the rest muscle electrical activity will be assessed by hip bone mineral density, bone mineral content and serum sclerostin level. The right hip bone mineral density (BMD) and BMC will be evaluated by bone densitometer (Norland). Plasma sclerostin level will be measured by using Human Sclerostin ELISA kıt before and after vibration.

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Intervention Model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: The Effects Of Femur On The Resting Myoelectrical Activity Of Contralateral Adductor Muscle During Unilateral Lower Extremity Vibration: Bone Myoregulation Reflex
Study Start Date : March 2011
Primary Completion Date : November 2012
Study Completion Date : December 2012
Arms and Interventions

Arm Intervention/treatment
Experimental: Whole-body vibration
whole body vibration will be applied the right lower limb.
Other: Whole-body vibration
Frequency: 40 Hz, vibration amplitude: 2 mm, duration: 60 sec
Other Name: Cyclic mechanical loading

Outcome Measures

Primary Outcome Measures :
  1. Vibration-induced contralateral muscle electrical activity [ Time Frame: 3 month ]

Eligibility Criteria

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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Age: 20-40 yrs
  • Gender: Male
  • Volunteer
  • Healthy status: Patients having hypoesthesia in his leg and Healthy subjects
  • Dominant hand:Right-handed

Exclusion Criteria:

  • Bone diseases (osteoporosis, osteomalacia, paget's disease, neoplasm, etc),
  • Systemic diseases (cardiovascular, endocrine, infections etc),
  • Myopathy-tendinopathy
  • Lower limb joint disease
  • Vertigo
  • Obesity (BMI >30 kg/m2)
  • Professional sportsman
  • Male doing regular sports activities
  • Skin disease in lower limb
  • Non-cooperative subject
  • Hemolysis of blood sample
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01419782

Bagcilar Training & Research Hospital
Istanbul, Turkey
Sponsors and Collaborators
Bagcilar Training and Research Hospital
Principal Investigator: ILHAN KARACAN, MD Bagcilar Training & Research Hospital
More Information

Responsible Party: Ilhan Karacan, Clinical Associated Professor, ILHAN KARACAN, Bagcilar Training and Research Hospital
ClinicalTrials.gov Identifier: NCT01419782     History of Changes
Other Study ID Numbers: BEAH FTR-5
First Posted: August 18, 2011    Key Record Dates
Last Update Posted: May 7, 2013
Last Verified: May 2013

Keywords provided by Ilhan Karacan, Clinical Associated Professor, Bagcilar Training and Research Hospital:
rest muscle electrical activity
whole-body vibration