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Combined Intensive and Conventional Exercise on Nonalcoholic Fatty Liver Disease (NAFLD)

This study has been completed.
Information provided by (Responsible Party):
Xiao-Ying Li, Shanghai Jiao Tong University School of Medicine Identifier:
First received: August 15, 2011
Last updated: August 28, 2014
Last verified: August 2014
The prevalence of NAFLD is 50-70% in obese people. A decrease of calorie intake and increase of physical activity are recommended as an effective approach for the prevention and treatment of NAFLD. However, the exercise model for NAFLD intervention is understudied. In the present study we aim to compare the effect of intensive and conventional exercise interventions on NAFLD.

Condition Intervention Phase
Non-alcoholic Fatty Liver Disease (NAFLD)
Other: Intensive exercise
Other: Conventional exercise
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Combined Intensive and Conventional Exercise Intervention of Nonalcoholic Fatty Liver Disease

Resource links provided by NLM:

Further study details as provided by Shanghai Jiao Tong University School of Medicine:

Primary Outcome Measures:
  • Change of intrahepatic triglyceride contents [ Time Frame: 12 months ]

Secondary Outcome Measures:
  • Change of body weight [ Time Frame: 12 months ]
  • Change of waist circumference [ Time Frame: 12 months ]
  • Change of body fat [ Time Frame: 12 months ]
  • Change of abdominal fat [ Time Frame: 12 montshs ]
  • Change of carotid intima-media thickness [ Time Frame: 12 months ]
  • Change of cardiovascular risk factors (Blood pressure, lipids, glucose) [ Time Frame: 12 months ]
  • Change of insulin resistance [ Time Frame: 12 months ]

Enrollment: 220
Study Start Date: August 2011
Study Completion Date: December 2013
Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Intensive exercise
The subjects receive an intensive exercise for 6 months and a subsequent conventional exercise for another 6 months.
Other: Intensive exercise
Subjects conduct an aerobic exercise at 65-80% maximum oxygen consumption for 30 minutes each day, five days a week, totally for 6 months.Subsequently, moderate physical activity(3.0-6.0 MET s) at 150 min/wk for 6 months.
No Intervention: Lifestyle counseling
Subjects receive a general lifestyle counseling for 12 months
Experimental: Regular exercise
Subjects receive conventional exercise for 12 months
Other: Conventional exercise
Subjects receive moderate physical activity(3.0-6.0 MET s) at 150 min/wk(30 min per day, five days a week) for 12 months.


Ages Eligible for Study:   40 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
  1. Subjects with NAFLD determined by MRS ;
  2. Age 40-65 years old;
  3. Waist circumference> 90cm for men and > 85cm for women.
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Please refer to this study by its identifier: NCT01418027

The First Hospital Affiliated to Xiamen University
Xiamen, China
Sponsors and Collaborators
Shanghai Jiao Tong University School of Medicine
Principal Investigator: Xiaoying Li, MD,PhD Shanghai Jiao Tong University School of Medicine
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Xiao-Ying Li, Professor, Shanghai Jiao Tong University School of Medicine Identifier: NCT01418027     History of Changes
Other Study ID Numbers: CCEMD011
Study First Received: August 15, 2011
Last Updated: August 28, 2014

Keywords provided by Shanghai Jiao Tong University School of Medicine:
hepatic triglycerides

Additional relevant MeSH terms:
Liver Diseases
Fatty Liver
Non-alcoholic Fatty Liver Disease
Digestive System Diseases processed this record on May 24, 2017