Nutrient Synergy in Beef and Stimulation of Protein Synthesis in Elderly
|Healthy||Dietary Supplement: 3 ounces of cooked, 85% lean ground beef Dietary Supplement: 20 grams beef protein isolate|
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Nutrient Synergy in Beef and Stimulation of Protein Synthesis in Elderly|
- skeletal muscle synthetic and breakdown rate [ Time Frame: day one ]Using stable isotope infusion/ingestion methodology, we will measure plasma and skeletal muscle metabolic rate. Our primary end points will be muscle protein fractional synthesis rate (FSR) and whole body protein turnover rate.
- concentrations of plasma amino acids, insulin and glucose [ Time Frame: day one ]Secondary endpoints are concentrations of plasma amino acids, insulin and glucose.
|Study Start Date:||July 2011|
|Study Completion Date:||January 2012|
|Primary Completion Date:||September 2011 (Final data collection date for primary outcome measure)|
Experimental: 3 ounces of cooked, 85% lean ground beef
Subjects would consume 3 ounces of cooked, 85% lean ground beef at one setting on one day.
Dietary Supplement: 3 ounces of cooked, 85% lean ground beef
Consumed once per subject.
Experimental: 20 grams of Beef protein isolate
Subjects would consume 20 grams of beef protein isolate dissolved into 200mL water at one setting on one day.
Dietary Supplement: 20 grams beef protein isolate
Subjects would drink 200 ml water mixed with 20 grams of beef protein isolate one time.
STUDY OBJECTIVES Primary: To compare the effects of consumption of a 3-ounce serving of beef to that of a 20g serving of BPI on skeletal muscle synthetic and breakdown rate in healthy elderly subjects.
Secondary: To investigate the effect the study products on plasma levels of amino acids, insulin, and glucose in healthy elderly subjects.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01415973
|United States, Arkansas|
|UAMS Center on Aging|
|Little Rock, Arkansas, United States, 72205|
|Principal Investigator:||Robert R Wolfe, PhD||UAMS|