Nutrient Synergy in Beef and Stimulation of Protein Synthesis in Elderly
|ClinicalTrials.gov Identifier: NCT01415973|
Recruitment Status : Completed
First Posted : August 12, 2011
Last Update Posted : January 18, 2012
|Condition or disease||Intervention/treatment|
|Healthy||Dietary Supplement: 3 ounces of cooked, 85% lean ground beef Dietary Supplement: 20 grams beef protein isolate|
STUDY OBJECTIVES Primary: To compare the effects of consumption of a 3-ounce serving of beef to that of a 20g serving of BPI on skeletal muscle synthetic and breakdown rate in healthy elderly subjects.
Secondary: To investigate the effect the study products on plasma levels of amino acids, insulin, and glucose in healthy elderly subjects.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Nutrient Synergy in Beef and Stimulation of Protein Synthesis in Elderly|
|Study Start Date :||July 2011|
|Primary Completion Date :||September 2011|
|Study Completion Date :||January 2012|
Experimental: 3 ounces of cooked, 85% lean ground beef
Subjects would consume 3 ounces of cooked, 85% lean ground beef at one setting on one day.
Dietary Supplement: 3 ounces of cooked, 85% lean ground beef
Consumed once per subject.
Experimental: 20 grams of Beef protein isolate
Subjects would consume 20 grams of beef protein isolate dissolved into 200mL water at one setting on one day.
Dietary Supplement: 20 grams beef protein isolate
Subjects would drink 200 ml water mixed with 20 grams of beef protein isolate one time.
- skeletal muscle synthetic and breakdown rate [ Time Frame: day one ]Using stable isotope infusion/ingestion methodology, we will measure plasma and skeletal muscle metabolic rate. Our primary end points will be muscle protein fractional synthesis rate (FSR) and whole body protein turnover rate.
- concentrations of plasma amino acids, insulin and glucose [ Time Frame: day one ]Secondary endpoints are concentrations of plasma amino acids, insulin and glucose.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01415973
|United States, Arkansas|
|UAMS Center on Aging|
|Little Rock, Arkansas, United States, 72205|
|Principal Investigator:||Robert R Wolfe, PhD||UAMS|