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Target Site Pharmacokinetics of Doripenem at Steady State in Intubated Intensive Care Patients

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01414959
First Posted: August 11, 2011
Last Update Posted: August 29, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Markus Zeitlinger, Medical University of Vienna
  Purpose
The investigators will measure the pharmacokinetics of doripenem in skeletal muscle, subcutaneous adipose tissue, bronchoalveolar lavage and plasma of intubated intensive care patients.

Condition
Pneumonia Abdominal Infection Urinary Tract Infection

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Target Site Pharmacokinetics of Doripenem at Steady State in Intubated Intensive Care Patients

Further study details as provided by Markus Zeitlinger, Medical University of Vienna:

Biospecimen Retention:   Samples Without DNA
plasma broncheoalvoeolar lavage microdialysates

Enrollment: 16
Study Start Date: August 2011
Study Completion Date: July 2013
Primary Completion Date: July 2013 (Final data collection date for primary outcome measure)
Detailed Description:
Methods: microdialysis, blood sampling, bronchoalveolar lavage
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
intubated patients, intensive care
Criteria

Inclusion Criteria:

  • endotracheal intubation; pneumonia or complicated abdominal infection or complicated urinary tract infection

Exclusion Criteria:

  • allergy to doripenem, hemodialysis
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01414959


Locations
Austria
Med. Univ. of Vienna
Vienna, Austria, 1090
Sponsors and Collaborators
Medical University of Vienna
Investigators
Principal Investigator: Markus Zeitlinger, MD Medical Universit of Vienna
  More Information

Responsible Party: Markus Zeitlinger, Professor Dr., Medical University of Vienna
ClinicalTrials.gov Identifier: NCT01414959     History of Changes
Other Study ID Numbers: Dori_MD_ICU
First Submitted: August 10, 2011
First Posted: August 11, 2011
Last Update Posted: August 29, 2017
Last Verified: August 2017

Keywords provided by Markus Zeitlinger, Medical University of Vienna:
intensive care patient
intubation
(please change wording as you like!)

Additional relevant MeSH terms:
Infection
Communicable Diseases
Pneumonia
Urinary Tract Infections
Intraabdominal Infections
Lung Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Urologic Diseases