HCG Versus Spontaneous LH in Intrauterine Insemination (IUI ) Cycles
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We recently reported the superiority of the natural cycle to a natural cycle controlled by the administration of human chorionic gonadotropin (hCG) for planning the frozen-thawed embryo transfer cycles, demonstrating a probable negative impact of exogenous hCG on endometrial receptivity.Based on the above findings we conducted the first prospective study that assesses whether there is a difference in pregnancy rate after intrauterine insemination (IUI) in a natural cycle with spontaneous luteinizing hormone (LH) rise compared to natural cycles controlled by hCG for final ovulation.
Condition or disease
Spontaneous Triggering of Ovulation vs. Administration of Human Chorionic Gonadotropin in Patients Undergoing IUI
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Ages Eligible for Study:
18 Years to 36 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
age ≤ 36 years,
regular menstrual cycles,
body mass index (BMI) between 18 and 29 kg/m²,
basal levels of FSH (≤ 12 IU/l),
estradiol (≤ 80 pg/ml) and progesterone (≤ 1.6ng/ml) on day one of the cycle, normal hysterosalpingography (maximum 3 months prior starting the cycle).
The use of donor sperm was also accepted as inclusion criteria.