The Health Effect of Diet Rich in Nordic Berries (Berry)
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|ClinicalTrials.gov Identifier: NCT01414647|
Recruitment Status : Completed
First Posted : August 11, 2011
Last Update Posted : April 17, 2012
|Condition or disease||Intervention/treatment||Phase|
|Metabolic Syndrome Impaired Glucose Tolerance Low-grade Inflammation Dyslipidemia||Dietary Supplement: 300 g of strawberry, raspberry and cloudberry Dietary Supplement: 400 g of bilberry Other: Control diet||Not Applicable|
Berries are traditionally an important part of the Nordic diet. About 50 different berries are grown in the northern region, and about half of them are edible. Phenolic compounds are one of the most diverse group of secondary metabolites present in edible plants, and berries are especially rich in them. Flavonoids, phenolic acids, lignans and complex phenolic polymers (polymeric tannins) are typical for berries. Phenolic compounds are reported to have a variety of beneficial biological properties. They are potent antioxidants, and exhibit various other physiological activities including anti-inflammatory, antimicrobial, antiallergic, anticarcinogenic and antihypertensive activities. Epidemiological studies indicate that diet rich in phenolic compound correlates with lower risk of cancer and cardiovascular disease.
The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers and gene expression profile in peripheral blood mononuclear cells (PBMCs) in subjects with features of metabolic syndrome.
Randomized, controlled clinical intervention including 4 wk run-in period, 8 wk dietary intervention and 4 wk recovery period was conducted.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||56 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Effect of Diet Rich in Nordic Berries on Gut Microbiota, Glucose and Lipid Metabolism and Metabolism on Fenolic Compounds|
|Study Start Date :||January 2006|
|Actual Primary Completion Date :||December 2006|
|Actual Study Completion Date :||March 2010|
Strawberry, raspberry and cloudberry intervention for 8 weeks
Dietary Supplement: 300 g of strawberry, raspberry and cloudberry
100 g of strawberry puree, 100 g of frozen raspberries and 100 g frozen cloudberries were concumed daily for 8 weeks. Bilberry consumption was restricted.
Bilberry intervention for 8 weeks
Dietary Supplement: 400 g of bilberry
Equivalent amount to 400 g of fresh bilberries were consumed as 40 g of dried bilberries and as 200 g of frozen bilberries. Restriction of use of strawberries, raspberries and cloudberries were set.
No Intervention: C
Control diet intervention with restrictions in berry consumption
Other: Control diet
Control diet, ie. habitual diet with restriction of berry consumption was consumed for eight weeks
- Glucose level [ Time Frame: week 8 ]Fasting glucose level oral glucose tolerance status at study week 8
- Cholesterol level [ Time Frame: week 8 ]total, HDL and LDL cholesterol level at the study week 8
- Inflammation markers [ Time Frame: week 8 ]Various inflammation markers were measured at the study week 8
- Markers of sterol metabolism [ Time Frame: week 8 ]Markers of cholesterol absorption and synthesis were measured
- gene expression in PBMCs [ Time Frame: study week 8 ]Global gene expression analyses in peripheral mononuclear cells (PBMC)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01414647
|University of Eastern Finland, Dpet of Public Health and Clinical Nutrition|
|Kuopio, Finland, FIN-70211|
|Principal Investigator:||Riitta Törrönen, Adjunct Professor||University of Eastern Finland|