Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

The Health Effect of Diet Rich in Nordic Berries (Berry)

This study has been completed.
VTT Technical Research Centre, Finland
Information provided by (Responsible Party):
Marjukka Kolehmainen, University of Eastern Finland Identifier:
First received: August 10, 2011
Last updated: April 16, 2012
Last verified: April 2012
Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures. The findings regarding the possible decrease of low-grade inflammation are existing also in humans. Low-grade inflammation has been suggested to be a mechanistic link between obesity and its consequences on cardiometabolic health. The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers.

Condition Intervention
Metabolic Syndrome
Impaired Glucose Tolerance
Low-grade Inflammation
Dietary Supplement: 300 g of strawberry, raspberry and cloudberry
Dietary Supplement: 400 g of bilberry
Other: Control diet

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: The Effect of Diet Rich in Nordic Berries on Gut Microbiota, Glucose and Lipid Metabolism and Metabolism on Fenolic Compounds

Resource links provided by NLM:

Further study details as provided by University of Eastern Finland:

Primary Outcome Measures:
  • Glucose level [ Time Frame: week 8 ]
    Fasting glucose level oral glucose tolerance status at study week 8

  • Cholesterol level [ Time Frame: week 8 ]
    total, HDL and LDL cholesterol level at the study week 8

  • Inflammation markers [ Time Frame: week 8 ]
    Various inflammation markers were measured at the study week 8

Secondary Outcome Measures:
  • Markers of sterol metabolism [ Time Frame: week 8 ]
    Markers of cholesterol absorption and synthesis were measured

  • gene expression in PBMCs [ Time Frame: study week 8 ]
    Global gene expression analyses in peripheral mononuclear cells (PBMC)

Enrollment: 56
Study Start Date: January 2006
Study Completion Date: March 2010
Primary Completion Date: December 2006 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: SRC
Strawberry, raspberry and cloudberry intervention for 8 weeks
Dietary Supplement: 300 g of strawberry, raspberry and cloudberry
100 g of strawberry puree, 100 g of frozen raspberries and 100 g frozen cloudberries were concumed daily for 8 weeks. Bilberry consumption was restricted.
Experimental: BB
Bilberry intervention for 8 weeks
Dietary Supplement: 400 g of bilberry
Equivalent amount to 400 g of fresh bilberries were consumed as 40 g of dried bilberries and as 200 g of frozen bilberries. Restriction of use of strawberries, raspberries and cloudberries were set.
No Intervention: C
Control diet intervention with restrictions in berry consumption
Other: Control diet
Control diet, ie. habitual diet with restriction of berry consumption was consumed for eight weeks

Detailed Description:

Berries are traditionally an important part of the Nordic diet. About 50 different berries are grown in the northern region, and about half of them are edible. Phenolic compounds are one of the most diverse group of secondary metabolites present in edible plants, and berries are especially rich in them. Flavonoids, phenolic acids, lignans and complex phenolic polymers (polymeric tannins) are typical for berries. Phenolic compounds are reported to have a variety of beneficial biological properties. They are potent antioxidants, and exhibit various other physiological activities including anti-inflammatory, antimicrobial, antiallergic, anticarcinogenic and antihypertensive activities. Epidemiological studies indicate that diet rich in phenolic compound correlates with lower risk of cancer and cardiovascular disease.

The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers and gene expression profile in peripheral blood mononuclear cells (PBMCs) in subjects with features of metabolic syndrome.

Randomized, controlled clinical intervention including 4 wk run-in period, 8 wk dietary intervention and 4 wk recovery period was conducted.


Ages Eligible for Study:   50 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • overweight (BMI 26-39 kg/m2), and two of the following:
  • elevated fasting plasma glucose in the absence of diabetes (5.6-6.9 mmol/l)
  • abnormal serum lipid concentration: fasting serum triglyceride concentration >1.7 mmol/L, fasting serum HDL cholesterol <1.0 mmol/L (males) or <1.3 mmol/L (females))
  • waist circumference >102 cm (males) or >88 cm (females)
  • blood pressure >130/85 mmHg

Exclusion Criteria:

  • chronic diseases
  • use of lipid lowering medication
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01414647

University of Eastern Finland, Dpet of Public Health and Clinical Nutrition
Kuopio, Finland, FIN-70211
Sponsors and Collaborators
Marjukka Kolehmainen
VTT Technical Research Centre, Finland
Principal Investigator: Riitta Törrönen, Adjunct Professor University of Eastern Finland
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Marjukka Kolehmainen, Senior scientist, University of Eastern Finland Identifier: NCT01414647     History of Changes
Other Study ID Numbers: 124//2005
40361/05 ( Other Grant/Funding Number: Tekes, National Technology Agency of Finland )
Study First Received: August 10, 2011
Last Updated: April 16, 2012

Keywords provided by University of Eastern Finland:
Vaccinium myrtillus
Metabolic syndrome
Glucose metabolism
Lipid metabolism
Gene expression

Additional relevant MeSH terms:
Metabolic Syndrome X
Glucose Intolerance
Pathologic Processes
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Lipid Metabolism Disorders
Hyperglycemia processed this record on May 23, 2017