Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer
|ClinicalTrials.gov Identifier: NCT01414595|
Recruitment Status : Completed
First Posted : August 11, 2011
Last Update Posted : June 27, 2017
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies tissue samples from patients with non-small cell lung cancer.
|Condition or disease||Intervention/treatment|
|Lung Cancer||Genetic: DNA analysis Genetic: DNA methylation analysis Genetic: RNA analysis Genetic: gene expression analysis Genetic: polymorphism analysis Other: laboratory biomarker analysis Other: medical chart review|
- To identify and characterize single nucleotide variations (SNVs) in non-small cell lung cancer (NSCLC) specimens.
- To identify and characterize structural variations in the genomes of NSCLC specimens.
- To identify and characterize other genomic alterations including, but not limited to, expression profiling and methylation.
OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide variations, structural variations in the genomes, and other genomic alterations including, but not limited to, gene expression profiling and methylation. Clinical data related to disease, treatment, and recurrence from each patient sample is also collected.
|Study Type :||Observational|
|Actual Enrollment :||248 participants|
|Official Title:||Molecular Characterization of Lung Cancer: A Collaboration With the Cancer Genome Atlas Project (TGCA)|
|Study Start Date :||March 2012|
|Primary Completion Date :||February 2017|
CALGB 140202 outlines the standard procedures for sample procurement. Samples to be used for this project have already been obtained and are currently banked at the CALGB Pathology Coordinating Office (PCO) and the Lung Cancer Tissue Bank at Brigham and Women's Hospital.
|Genetic: DNA analysis Genetic: DNA methylation analysis Genetic: RNA analysis Genetic: gene expression analysis Genetic: polymorphism analysis Other: laboratory biomarker analysis Other: medical chart review|
- Identification and characterization of SNVs in primary adenocarcinoma of the lung or squamous cell carcinoma of the lung [ Time Frame: up to 5 years ]
- Identification and characterization of structural variations in the genomes of NSCLC [ Time Frame: up to 5 years ]
- Identification and characterization of other genomic alterations including, but not limited to, gene expression profiling and methylation [ Time Frame: up to 5 years ]
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01414595
|United States, California|
|Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center|
|Los Angeles, California, United States, 90048|
|United States, Delaware|
|Tunnell Cancer Center at Beebe Medical Center|
|Lewes, Delaware, United States, 19958|
|CCOP - Christiana Care Health Services|
|Newark, Delaware, United States, 19713|
|United States, Maryland|
|Greenebaum Cancer Center at University of Maryland Medical Center|
|Baltimore, Maryland, United States, 21201|
|Union Hospital of Cecil County|
|Elkton, Maryland, United States, 21921|
|United States, Missouri|
|Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis|
|Saint Louis, Missouri, United States, 63110|
|United States, New Jersey|
|Cancer Institute of New Jersey at Cooper - Voorhees|
|Voorhees, New Jersey, United States, 08043|
|United States, New York|
|Roswell Park Cancer Institute|
|Buffalo, New York, United States, 14263-0001|
|United States, North Carolina|
|Duke Cancer Institute|
|Durham, North Carolina, United States, 27710|
|United States, Rhode Island|
|Rhode Island Hospital Comprehensive Cancer Center|
|Providence, Rhode Island, United States, 02903|
|Providence, Rhode Island, United States, 02906|
|Study Chair:||Ramaswamy Govindan, MD||Washington University School of Medicine|