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Effect of Oxygen During Percutaneous Coronary Intervention for Pain Relief (OXYPAIN)

This study has been completed.
Information provided by (Responsible Party):
Region Skane Identifier:
First received: August 9, 2011
Last updated: August 9, 2012
Last verified: August 2012
Nasal oxygen is widely used as pain relief against ischemic pain during Percutaneous Coronary Intervention (PCI). However, to our knowledge no randomised clinical trials have tested this. In contrast, oxygen causes coronary artery vasoconstriction in man. Furthermore, a recent Cochrane meta-analysis has shown no evidence of beneficial effect of oxygen for patients with acute myocardial infarction (with normal blood saturation. The investigators therefore wanted to examine if oxygen reduces ischemic pain during PCI for stable angina or NSTEMI.

Condition Intervention Phase
Angina Drug: Nasal oxygen Drug: Regular nasal air Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Phase II Randomised Study of Nasal Oxygen Treatment for Pain Relief During Percutaneous Coronary Interventions

Resource links provided by NLM:

Further study details as provided by Region Skane:

Primary Outcome Measures:
  • Chest pain measured with VAS [ Time Frame: 1 h ]
    After PCI patient is asked in a double blinded about maximum chest during PCI.

Secondary Outcome Measures:
  • Troponin-levels after PCI [ Time Frame: 2 days ]
    Peak troponin the first days after PCI

Enrollment: 300
Study Start Date: July 2011
Study Completion Date: June 2012
Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Nasal oxygen
3 liter per minute
Drug: Nasal oxygen
3 l oxygen
Placebo Comparator: Nasal Air
3 l regular nasal air
Drug: Regular nasal air
3 l nasal air


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Stable angina or NST-ACS undergoing PCI

Exclusion Criteria:

  • Blood oxygen <95%
  • Cognitive dysfunction
  • Intubation
  Contacts and Locations
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Please refer to this study by its identifier: NCT01413841

Skane University Hospital, Lund
Lund, Sweden, 22185
Sponsors and Collaborators
Region Skane
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Region Skane Identifier: NCT01413841     History of Changes
Other Study ID Numbers: DELUCA2
Study First Received: August 9, 2011
Last Updated: August 9, 2012

Keywords provided by Region Skane:
oxygen processed this record on September 21, 2017