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Coenzyme Q10 and Vitamin A, C, E in Relation to the Oxidative Stress, Antioxidant Enzyme Activity and Inflammation in Subjects With Metabolic Syndrome

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ClinicalTrials.gov Identifier: NCT01412476
Recruitment Status : Completed
First Posted : August 9, 2011
Last Update Posted : March 26, 2012
Information provided by:

Study Description
Brief Summary:
Metabolic syndrome (MS) is a significant risk factor of cardiovascular disease. However, the relationships between coenzyme Q10, antioxidant vitamins (Vitamin A, C, E) and the prevention of the risk of MS are still inconsistent. The purposes of this study are going to investigate the relation of coenzyme Q10, antioxidant vitamins concentration with the blood lipid levels, the markers of lipid peroxidation (TBARS), antioxidant enzymes activities (catalase, glutathione peroxidase and superoxide dismutase), and the inflammatory markers (hs-CRP,IL-6 and adiponectin). The investigators will recruit MS patients (case group, n = 100) and age-gender matched healthy subjects from previous study(n = 105) as a control group . The inclusion criteria of MS are according to the Bureau of Health Promotion, Department of Health in Taiwan (2007).Hopefully, the results of this study could provide the information to what has been know in MS subjects. The investigators expect coenzyme Q10 or antioxidant vitamins could be a preventive supplement to reduce the risk of MS.

Condition or disease
Metabolic Syndrome

Study Design

Study Type : Observational
Actual Enrollment : 72 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Study Start Date : August 2010
Study Completion Date : March 2012

Groups and Cohorts

case group
Subjects with metabolic syndrome
control group
Healthy individuals

Outcome Measures

Biospecimen Retention:   Samples Without DNA
Blood samples

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The investigators recruited MS patients (case group, n = 100). The inclusion criteria of MS are according to the Bureau of Health Promotion, Department of Health in Taiwan (2007). The health subject were recrited from previous study (n = 105).

Inclusion Criteria:

  • Metabolic syndrome
  • Healthy individuals with normal blood biochemical values.

Exclusion Criteria:

  • Age < 18y
  • Antioxidant vitamins supplements use
  • Pregnant women
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01412476

Ping-Ting Lin
Taichung, Taiwan
Sponsors and Collaborators
Chung Shan Medical University
National Science Council, Taiwan
Principal Investigator: Ping-Ting Lin, Ph.D. Chung Shan Medical University
More Information

Responsible Party: Ping-Ting Lin, Chung Shan Medical University
ClinicalTrials.gov Identifier: NCT01412476     History of Changes
Other Study ID Numbers: CS09155
First Posted: August 9, 2011    Key Record Dates
Last Update Posted: March 26, 2012
Last Verified: March 2012

Additional relevant MeSH terms:
Metabolic Syndrome X
Pathologic Processes
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases