Effects of Monosodium Glutamate on Energy Balance and Eating Behavior
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|ClinicalTrials.gov Identifier: NCT01410838|
Recruitment Status : Completed
First Posted : August 5, 2011
Last Update Posted : May 21, 2015
|Condition or disease||Intervention/treatment||Phase|
|Obesity Weight Gain Food Preferences||Other: Broth||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||44 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||Effects of Ingesting Monosodium Glutamate (MSG) on Energy Balance and Eating Behavior Following Moderate Energy Restriction and Weight Loss in Overweight Women|
|Study Start Date :||August 2011|
|Actual Primary Completion Date :||August 2014|
|Actual Study Completion Date :||August 2014|
Placebo Comparator: Broth- NaCl
Sodium chloride containing broth matched for sodium content to the MSG broth
200 mL of sodium chloride containing broth, consumed three times per day
Active Comparator: Broth- MSG
MSG containing broth with the same sodium content as the placebo comparator.
200 mL of MSG containing broth consumed three times per day
- Change in body weight [ Time Frame: weeks 11, 12, and 25 ]Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss.
- Change in body fat [ Time Frame: weeks 11 and 25 ]Volunteers will have their body fat measured by DEXA (Dual X-ray Absorptiometry) to determine the effect of MSG on body fat regain following weight loss.
- Change in eating behavior [ Time Frame: weeks 11, 12 and 25 ]The effect of MSG on eating behavior will be measured using questionnaires, sensory evaluation testing, stress responsivity, and liking and wanting tests, and appetite assessments.
- Change in resting energy expenditure [ Time Frame: weeks 11, 12, and 25 ]The effect of MSG on resting energy expenditure will be measured using respiratory gas exchange using a metabolic cart system.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01410838
|United States, California|
|Western Human Nutrition Center, University of California Davis|
|Davis, California, United States, 95616|
|Principal Investigator:||Kevin Laugero, PhD||WHNRC, ARS, University of California Davis|