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Effects of Monosodium Glutamate on Energy Balance and Eating Behavior

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ClinicalTrials.gov Identifier: NCT01410838
Recruitment Status : Completed
First Posted : August 5, 2011
Last Update Posted : May 21, 2015
Sponsor:
Collaborator:
Information provided by (Responsible Party):

Study Description
Brief Summary:
This study will test whether regular consumption of Monosodium Glutamate (MSG) immediately prior to each of the three major meals (breakfast, lunch, dinner) inhibits body weight and fat regain following a period of moderate, yet clinically significant weight loss.

Condition or disease Intervention/treatment
Obesity Weight Gain Food Preferences Other: Broth

Detailed Description:
The proposed study enables us to assess the long term effects of consuming MSG on body weight regain following weight loss.

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 44 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Ingesting Monosodium Glutamate (MSG) on Energy Balance and Eating Behavior Following Moderate Energy Restriction and Weight Loss in Overweight Women
Study Start Date : August 2011
Primary Completion Date : August 2014
Study Completion Date : August 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Body Weight
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Placebo Comparator: Broth- NaCl
Sodium chloride containing broth matched for sodium content to the MSG broth
Other: Broth
200 mL of sodium chloride containing broth, consumed three times per day
Active Comparator: Broth- MSG
MSG containing broth with the same sodium content as the placebo comparator.
Other: Broth
200 mL of MSG containing broth consumed three times per day


Outcome Measures

Primary Outcome Measures :
  1. Change in body weight [ Time Frame: weeks 11, 12, and 25 ]
    Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss.


Secondary Outcome Measures :
  1. Change in body fat [ Time Frame: weeks 11 and 25 ]
    Volunteers will have their body fat measured by DEXA (Dual X-ray Absorptiometry) to determine the effect of MSG on body fat regain following weight loss.

  2. Change in eating behavior [ Time Frame: weeks 11, 12 and 25 ]
    The effect of MSG on eating behavior will be measured using questionnaires, sensory evaluation testing, stress responsivity, and liking and wanting tests, and appetite assessments.

  3. Change in resting energy expenditure [ Time Frame: weeks 11, 12, and 25 ]
    The effect of MSG on resting energy expenditure will be measured using respiratory gas exchange using a metabolic cart system.


Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   19 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Women
  • Age 19-45
  • BMI 27-35
  • Blood pressure <140/90
  • Non-smoking

Exclusion Criteria:

  • Anemic: hgb < 11.5 mg/dL
  • Sensitivity to MSG (self reported)
  • Pregnant or planning to get pregnant
  • Taking medication for hypertension, depression, or weight loss
  • Diabetic
  • Vegetarian
  • MRI Contraindications: internal metal, braces on teeth, history of metal in the eye, claustrophobia
  • blindness or heavily corrected vision
  • not fluent in English
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01410838


Locations
United States, California
Western Human Nutrition Center, University of California Davis
Davis, California, United States, 95616
Sponsors and Collaborators
USDA, Western Human Nutrition Research Center
Ajinomoto USA, INC.
Investigators
Principal Investigator: Kevin Laugero, PhD WHNRC, ARS, University of California Davis
More Information

Additional Information:
Responsible Party: USDA, Western Human Nutrition Research Center
ClinicalTrials.gov Identifier: NCT01410838     History of Changes
Other Study ID Numbers: WHNRC 222718-2
First Posted: August 5, 2011    Key Record Dates
Last Update Posted: May 21, 2015
Last Verified: August 2014

Keywords provided by USDA, Western Human Nutrition Research Center:
Obesity
Food preferences
Eating Behavior

Additional relevant MeSH terms:
Weight Gain
Body Weight Changes
Body Weight
Signs and Symptoms