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Metabolomic Analysis of Exhaled Breath Condensates in Patients With COPD and Bronchiectasis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2011 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01410422
First Posted: August 5, 2011
Last Update Posted: August 5, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Taiwan University Hospital
  Purpose
Metabolomics is a large-scale approach to monitoring the compounds involved in cellular processes. It may reflect changes in biological function. Collection of exhaled breath is a newly developed, noninvasive method that may allow clinicians and researchers to assess biochemical profiles in the airway. This study is conducted for the metabolomic analysis of the exhaled gas in patients with Chronic Obstructive Pulmonary Disease (COPD) and bronchiectasis.

Condition
COPD Bronchiectasis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Exhaled Breath Analysis in Patients With COPD and Bronchiectasis

Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   Samples Without DNA
Breath condensate, blood, urine

Estimated Enrollment: 250
Study Start Date: May 2011
Estimated Study Completion Date: April 2014
Groups/Cohorts
COPD
COPD
Bronchiectasis
Bronchiectasis

Detailed Description:
Metabolomics is a large-scale approach to monitoring as many as possible of the compounds involved in cellular processes in a single assay to derive metabolic profiles. Compared with genomics or proteomics, metabolomics reflects changes in phenotype and therefore function. Collection of exhaled breath condensate (EBC) is a newly developed, noninvasive method that may allow clinicians and researchers to assess biochemical profiles in the alveolar lining fluid. The aims of this study are: (1)Collecting and metabolomic profiling of the EBCs from patients with COPD/bronchiectasis; (2) Comparing the profiles of these patients obtained during stable and acute exacerbation periods; (3) Comparing the profiles of these patients with and without Pseudomonas colonization/infection; (4) Correlation of EBC metabolomic profiles with clinical phenotypes, severity and outcomes of these patients.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with COPD and bronchiectasis
Criteria

Inclusion Criteria:

  • patients with COPD or bronchiectasis

Exclusion Criteria:

  • not willing to sign ICF
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01410422


Contacts
Contact: Ping-Hung Kuo 886-972651067 Kph712@ntuh.gov.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Ping-Hung Kuo, M.D.    886-972651067      
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Ping-Hung Kuo, M.D. National Taiwan University Hospital
  More Information

Responsible Party: Ping-Hung Kuo, MD., National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT01410422     History of Changes
Other Study ID Numbers: 201103010RC
First Submitted: August 4, 2011
First Posted: August 5, 2011
Last Update Posted: August 5, 2011
Last Verified: May 2011

Keywords provided by National Taiwan University Hospital:
COPD
Bronchiectasis
Metabolomics

Additional relevant MeSH terms:
Bronchiectasis
Bronchial Diseases
Respiratory Tract Diseases