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Inspiratory Muscle Training in Pulmonary Hypertension

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2011 by Hospital de Clinicas de Porto Alegre.
Recruitment status was:  Recruiting
Associação Fundo de Incentivo à Pesquisa
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Information provided by:
Hospital de Clinicas de Porto Alegre Identifier:
First received: April 20, 2011
Last updated: August 4, 2011
Last verified: August 2011
The purpose of this study is evaluate the effect the inspiratory muscle training on the functional capacity of patients with pulmonary hypertension.

Condition Intervention
Pulmonary Hypertension
Other: Inspiratory muscle training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Inspiratory Muscle Training Effect on the Functional Capacity and the Quality of Life in Chronic Pulmonary Hypertension

Resource links provided by NLM:

Further study details as provided by Hospital de Clinicas de Porto Alegre:

Primary Outcome Measures:
  • The distance traveled in meters in the six minutes walk test after 8 weeks the inspiratory muscle training [ Time Frame: patients will be monitored throughout the training protocol for 8 weeks ]

Secondary Outcome Measures:
  • Increase in score of quality of life questionnaire after 8 weeks the inspiratory muscle training [ Time Frame: patients will be monitored throughout the training protocol for 8 weeks ]

Estimated Enrollment: 34
Study Start Date: December 2009
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: Inspiratory muscle training
    The load is adjusted weekly in thirty percent of maximal inspiratory pressure of the subject.
Detailed Description:
Pulmonary hypertension (PH) is a syndrome, in the case of hemodynamic alteration of a number of diseases and processes, such as the progressive increase in pulmonary vascular resistance, right heart failure and early death. Frequently patients with PH have reduced functional capacity, quality of life and survival. It was demonstrated recently that patients with HP also have inspiratory muscle weakness, possibly further increase the fatigue and dyspnea during exercise. To meet this need, inspiratory muscle training can lead to significant improvement in respiratory muscle strength, exercise tolerance and dyspnea, thus resulting in reduction of discomfort during activities of daily living, increase in exercise capacity and improved quality of life in different situations.

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Clinical diagnosis pulmonary hypertension
  • World Health Organization (WHO) functional class II to IV
  • inspiratory muscle weakness

Exclusion Criteria:

  • obesity
  • chronic obstructive pulmonary disease
  • orthopedic and neurological disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01410279

Contact: Pedro Dal'Lago 55(51)3303-8796
Contact: Glória M Ferreira 55(51)9284.0703

Hospital de Clinica de Porto Alegre Recruiting
Porto Alegre, Rio Grande do Sul, Brazil, 90035003
Contact: Pedro Dal'Lago    +55(51)3303-8796   
Contact: Glória M Ferreira    +55(51)9284-0703   
Principal Investigator: Pedro Dal'Lago         
Sub-Investigator: Glória M Ferreira         
Sub-Investigator: Sérgio M Barreto         
Sponsors and Collaborators
Hospital de Clinicas de Porto Alegre
Associação Fundo de Incentivo à Pesquisa
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Principal Investigator: Pedro Dal'Lago Hospital de Clínicas de Porto Alegre
  More Information

Responsible Party: Pedro Dal'Lago, UFCSPA Identifier: NCT01410279     History of Changes
Other Study ID Numbers: 09032
Study First Received: April 20, 2011
Last Updated: August 4, 2011

Keywords provided by Hospital de Clinicas de Porto Alegre:
pulmonary hypertension
inspiratory muscle training
inspiratory muscle weakness
pulmonary functional
functional capacity
quality of life

Additional relevant MeSH terms:
Hypertension, Pulmonary
Respiratory Aspiration
Vascular Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Pathologic Processes processed this record on May 22, 2017