Effect of Heart-lung-machine on Selenium Status of Cardiac Surgical Patients Undergoing Coronary Bypass Surgery (SEOPCAB)
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|ClinicalTrials.gov Identifier: NCT01409057|
Recruitment Status : Completed
First Posted : August 3, 2011
Last Update Posted : December 12, 2012
|Condition or disease|
To produce two comparable groups of patients, the characteristics are recorded using EURO-Score; additionally the groups are "matched" (Matched-Pairs-Analysis).
All patients are operated by the same surgeon (senior physician Dr. A.K. Menon) under general anaesthesia through median sternotomy with elective or urgent indications.
After induction of anaesthesia, within the first hour after admission to the Intensive Care Unit (ICU) and every further morning in the ICU or Intermediate Care Station (IMC), 10ml blood are removed by a central venous catheter, allowing to measure blood selenium levels in whole blood by electrothermal atomic absorption spectrometry.
All blood draws will be held on vascular access, which is lying independently of the study participation for surgery or for intensive care treatment. The blood samples will be stored until completion of the study and its evaluation (up to 24 months) and are discarded afterwards. All data collected are recorded on a documentation sheet.
|Study Type :||Observational|
|Actual Enrollment :||46 participants|
|Official Title:||SEOPCAB: Effect of Heart-lung-machine on Selenium Status of Cardiac Surgical Patients Undergoing Coronary Bypass Surgery|
|Study Start Date :||June 2010|
|Actual Primary Completion Date :||August 2012|
|Actual Study Completion Date :||December 2012|
No heart lung machine
Heart lung machine
Coronary artery disease
- Perioperative serum levels of selenium [ Time Frame: 48 hours ]Perioperative serum levels of selenium in patients undergoing either conventional cardiac surgery with the use of cardiopulmonary-bypass (CPB) or without use of CPB on beating heart.
- Perioperative serum levels of macrophage migration inhibitory factor (MIF) [ Time Frame: 48 hours ]Perioperative serum levels of macrophage migration inhibitory factor (MIF)in patients undergoing either conventional cardiac surgery with the use of cardiopulmonary-bypass (CPB) or without use of CPB on beating heart.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01409057
|University Hospital Aachen|
|Aachen, Germany, 52074|
|Principal Investigator:||Steffen Rex, Dr. med.||University Hospital, Aachen|