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Early- and Late-onset Candidemia

This study has been completed.
Merck Sharp & Dohme Corp.
Information provided by (Responsible Party):
Giovanni Di Perri, University of Turin, Italy Identifier:
First received: July 28, 2011
Last updated: December 2, 2014
Last verified: December 2014

A timing diagnosis of candidemia is as important as the correct choice of empiric or targeted antifungal therapy. In the last years a growing body of knowledge has better characterized health-care associated (HCA) infections, which have been described in 2002 in outpatients with MRSA bloodstream infections. So far there is no compelling evidence that patients with HCA infections may develop candidemia before the usual timing of around 20-25 days after admission. Risk factors associated with HCA infections are represented by admission from long term chronic care facilities (LTCF), haemodialysis, previous admission or parenteral broad spectrum antibiotics. There are few data HCA features and early onset candidemias in the published literature.

In this proposal, the investigators aim at studying early-onset candidemia in a retrospective study in one of the largest referral hospital in Italy with a consistent range of specialties ranging (bone marrow transplant, solid organ transplant, immunosuppressed patients, ICU, complex surgery). The investigators speculate that patients with candidemia diagnosed within 10 days (early-onset) by the admission have different risk factors and prognosis of those with a late diagnosis.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Early- and Late-onset Candidemia: A Retrospective Study

Further study details as provided by University of Turin, Italy:

Primary Outcome Measures:
  • Mortality [ Time Frame: 30 days ]

Enrollment: 400
Study Start Date: May 2011
Study Completion Date: June 2012
Primary Completion Date: February 2012 (Final data collection date for primary outcome measure)
Candidemia patients
Patients with diagnosis of candidemia


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The selection of patients for inclusion will be based on microbiological data (with suscesptibilty patterns of the various antifungals) extracted from the computerized archive with search for Candida spp. and "blood" either peripheral or from a central venous catheter. Candida isolated from a removed CVC tip will not be considered. The candidemia will also be defined early or late based on the time elapsed between hospital admission and diagnosis (≤ 10 days early, > 10 days late candidemia).

Inclusion Criteria:

  • Candidemia diagnosed with positive blood culture either from a peripheral vein or CVC

Exclusion Criteria:

  • Candida isolated from a removed CVC tip will not be considered
  Contacts and Locations
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Please refer to this study by its identifier: NCT01406093

Hospital San Giovanni Battista - Molinette
Torino, Italy, 10100
Sponsors and Collaborators
Giovanni Di Perri
Merck Sharp & Dohme Corp.
Principal Investigator: Giovanni Di Perri, MD, PhD University of Turin, Italy
Study Chair: Francesco G De Rosa, MD University of Turin, Italy
  More Information

Responsible Party: Giovanni Di Perri, Early- and Late-onset Candidemia, University of Turin, Italy Identifier: NCT01406093     History of Changes
Other Study ID Numbers: EOC1-11
Study First Received: July 28, 2011
Last Updated: December 2, 2014

Keywords provided by University of Turin, Italy:
Health-care associated

Additional relevant MeSH terms:
Candidiasis, Invasive
Systemic Inflammatory Response Syndrome
Pathologic Processes processed this record on April 27, 2017