System for Measuring Non-invasive Blood Flow in the Tracheobronchial Mucosa: Validation of Reproducibility
|ClinicalTrials.gov Identifier: NCT01402752|
Recruitment Status : Withdrawn (20131209 Regulatory authorization is currently blocked at the ANSM.)
First Posted : July 26, 2011
Last Update Posted : June 19, 2017
|Condition or disease||Intervention/treatment||Phase|
|Healthy||Biological: Blood flow to the tracheo-bronchial mucosa||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||System for Measuring Non-invasive Blood Flow in the Tracheobronchial Mucosa: Validation of Reproducibility|
|Study Start Date :||November 2013|
|Estimated Primary Completion Date :||March 2014|
|Estimated Study Completion Date :||March 2014|
Experimental: All patients
All patients included in this study according to stated inclusion and exclusion criteria.
Biological: Blood flow to the tracheo-bronchial mucosa
Measurement of blood flow to the tracheo-bronchial mucosa via differential absorption of diluted dimethyl ether tracer gas.
- The reproducibility of two measures of Qaw at a five minute interval [ Time Frame: Five minutes ]Qaw is the blood flow measured in the tracheobronchial mucosa. Qaw = VDME/(FDME*alpha*10s) where VDME is the volume of dimethyl-ether exhaled (ml), FDME is the mean concentration of dimethyl-ether (%), alpha is the Bunsen coefficient for the dissolution of dimethyl ether in tissues and blood at 37°C (i.e. 9ml/ml).
- The time necessary to complete one measure of Qaw (minutes) [ Time Frame: Day 1 ]Qaw = blood flow measured in the tracheobronchial mucosa
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01402752
|Principal Investigator:||Charles Le Merre, MD||Centre Hospitalier Universitaire de Nîmes|