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Effects of Inspiratory Muscle Training in COPD (IMTCO)

This study has been completed.
Information provided by (Responsible Party):
Daniel Langer, Katholieke Universiteit Leuven Identifier:
First received: July 18, 2011
Last updated: March 12, 2017
Last verified: March 2017
The additional effect of inspiratory muscle training as an adjunct to a general exercise training program in patients with COPD with inspiratory muscle weakness will be studied. The main hypothesis is that inspiratory muscle training combined with an exercise training program improves functional exercise capacity more than an exercise training program without the addition of an inspiratory muscle training program.

Condition Intervention Phase
Inspiratory Muscle Weakness
Procedure: Inspiratory Muscle Training
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Participant, Care Provider, Investigator, Outcomes Assessor
Primary Purpose: Treatment
Official Title: Effects of Inspiratory Muscle Training in Patients With Chronic Obstructive Pulmonary Disease - a Randomized Controlled Trial

Further study details as provided by Katholieke Universiteit Leuven:

Primary Outcome Measures:
  • 6-Minute Walking Distance [ Time Frame: Baseline and 8 weeks follow-up ]

Enrollment: 208
Actual Study Start Date: February 2012
Study Completion Date: December 2016
Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Inspiratory Muscle Training
Inspiratory Muscle Training
Procedure: Inspiratory Muscle Training
Three times daily inspiratory muscle training (2x30 breaths) at an intensity of >50% Pi,max
Placebo Comparator: Sham IMT
Sham Inspiratory Muscle Training
Procedure: Inspiratory Muscle Training
Three times daily inspiratory muscle training (2x30 breaths) at an intensity of >50% Pi,max


Ages Eligible for Study:   40 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with COPD
  • Eligible to participate in a exercise training intervention of 8 weeks
  • Pi,max <60cmH2O or <50% of the predicted normal value

Exclusion Criteria:

  • Major comorbidities preventing successful participation in an 8 week exercise training intervention
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Please refer to this study by its identifier: NCT01397396

University Hospital Leuven
Leuven, Belgium, 3000
Sponsors and Collaborators
Katholieke Universiteit Leuven
Principal Investigator: Rik Gosselink, PT, PhD Katholieke Universiteit Leuven
  More Information

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Daniel Langer, Dr Daniel Langer, Katholieke Universiteit Leuven Identifier: NCT01397396     History of Changes
Other Study ID Numbers: S52852
Study First Received: July 18, 2011
Last Updated: March 12, 2017

Additional relevant MeSH terms:
Respiratory Aspiration
Muscle Weakness
Respiration Disorders
Respiratory Tract Diseases
Pathologic Processes
Muscular Diseases
Musculoskeletal Diseases
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on April 28, 2017