Evaluating Erythropoietin as an Indicator for Possible Kidney Injury After Cardiac Surgery (EPO)
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|ClinicalTrials.gov Identifier: NCT01393418|
Recruitment Status : Completed
First Posted : July 13, 2011
Last Update Posted : December 15, 2016
|Condition or disease||Intervention/treatment|
|Erythropoietin Acute Kidney Injury Renal Biomarker||Other: Cardiac Surgery|
Acute kidney injury (AKI) is a serious complication after cardiac surgery and cardio-pulmonary bypass. AKI is associated with high mortality.
Erythropoietin, a hormone produced by the kidneys, will be evaluated as a potential biomarker of kidney injury. Neutrophil gelatinase-associated lipocalin (NGAL) has been studied as a biomarker of kidney injury. Early kidney injury detection has been long sought and NGAL has been shown to be a promising biomarker. A troponinlike biomarker of AKI that is easily measured and capable of both early detection and risk stratification would represent an advancement in our ability to differentiate acute kidney injury from failure.
Investigating EPO as a biomarker may prove to have increased predictive value in the clinical care of cardiac surgery patients.
|Study Type :||Observational|
|Actual Enrollment :||80 participants|
|Official Title:||EPO: A Renal Biomarker After Cardiac Surgery|
|Study Start Date :||November 2010|
|Actual Primary Completion Date :||March 2012|
|Actual Study Completion Date :||March 2012|
|Subjects undergoing cardiac surgery||Other: Cardiac Surgery|
- Renal injury/Failure [ Time Frame: 18 Hours after surgery ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01393418
|United States, Michigan|
|University of Michigan Hospital|
|Ann Arbor, Michigan, United States, 48109|
|Principal Investigator:||Yasser El Kouatli, MD||Department of Anesthesiology, University of Michigan|