Brain Health and Exercise in Schizophrenia (PEHP)
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ClinicalTrials.gov Identifier: NCT01392885 |
Recruitment Status
:
Enrolling by invitation
First Posted
: July 13, 2011
Last Update Posted
: January 18, 2018
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Condition or disease |
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Schizophrenia Schizoaffective Disorder Poor Memory |
Study Type : | Observational |
Estimated Enrollment : | 60 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Brain Health: Effects of Exercise on Hippocampal Volume and Memory Deficits in Persons With Schizophrenia |
Study Start Date : | July 2011 |
Actual Primary Completion Date : | June 2016 |
Estimated Study Completion Date : | December 2020 |
- Increase hippocampal volume with aerobic training in schizophrenic and healthy volunteers. [ Time Frame: Base-line, 8 and 12 weeks ]Hippocampal volumes will be measured from structural MRI scans. T1-weighted 3D SPGR (spoiled gradient recalled) and high-resilution T2- weighted structural images will be obtained for the purposes of volumetric assessment of the hippocampi and the whole brain
- Increases in hippocampal volumes will be positively associated with improvements in working memory performance in schizophrenia. [ Time Frame: Baseline, Week 4, 8 and 12. ]The Hopkins Verbal Learning Test (HVLT), will be used to assess memory function. Multiple versions of the HVLT exist (12) so practice effects will be minimized. The Rey-Osterrieth Complex Figure Test (ROCF), in which subjects are asked to reproduce a complex line drawing from memory, will be used to assess attention and working memory.
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 19 Years to 45 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Age 19 to 45 years
- Able to provide written, informed consent in English
- Patients may be on prescribed medications
- DSM-IV diagnosis of schizophrenia or schizoaffective disorder
- Normal visual acuity (or normal visual acuity achievable with corrective lenses)
- Physical ability to be engaged in a regular exercise program
Exclusion Criteria:
- A history of organic disorders (dementia, severe head injury, or developmental disorders such as autism, mental retardation, Down's Syndrome)
- A current DSM-IV diagnosis of substance dependence (during prior 12 months, excluding tobacco)
- Any history of DSM-IV diagnoses (Axis I) for other psychiatric disorders
- History of angina, heart attack or transient ischemic attacks
- Non-independent mobility or limb prostheses
- A history of severe head injury leading to loss of consciousness for > 5 minutes
- Contra-indications for neuroimaging (metal implants, non-removable orthodontic devices, severe claustrophobia, pregnancy, or surgeries within the previous 6 months)
- Currently already enrolled in a regular exercise program

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01392885
Canada, British Columbia | |
UBC Hospital | |
Vancouver, British Columbia, Canada, V6T 1Z3 |
Principal Investigator: | Donna J Lang, PhD | University of British Columbia, Dept. of Radiology | |
Study Chair: | William G Honer, Professor | University of British Columbia, Dept of Psychiatry | |
Study Chair: | Allen Thornton, Unspecified | Simon Fraser University | |
Study Chair: | Darren Warburton, Ass. Prof | University of British Columbia, Dept. of Human Kinetics | |
Study Chair: | Alexandra T Vertinsky, Clin. Instr. | University of British Columbia, Dept. of Radiology | |
Study Chair: | Sean Flynn, Ass. Prof. | University of British Columbia, Dept. of Psychiatry | |
Study Chair: | Alexander Rauscher, Ass. Prof. | University of British Columbia, Dept. of Radiology | |
Study Chair: | Geoffrey N Smith, Ass. Prof | University of British Columbia, Dept. of Psychiatry |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Dr. Donna Lang, PhD, Dr. Donna J. Lang, PhD, BC Mental Health and Addictions Research Institute |
ClinicalTrials.gov Identifier: | NCT01392885 History of Changes |
Other Study ID Numbers: |
231233-BSB |
First Posted: | July 13, 2011 Key Record Dates |
Last Update Posted: | January 18, 2018 |
Last Verified: | January 2018 |
Keywords provided by Dr. Donna Lang, PhD, BC Mental Health and Addictions Research Institute:
Schizophrenia Schizoaffective Disorder Brain Health |
Exercise Mental Health Poor memory |
Additional relevant MeSH terms:
Schizophrenia Psychotic Disorders Schizophrenia Spectrum and Other Psychotic Disorders Mental Disorders |