Brain Health and Exercise in Schizophrenia (PEHP)
To determine the effects of aerobic exercise on hippocampal volumes and severity of psychotic symptoms in a population of psychosis patients compared to healthy age/gender matched volunteers. Psychosis patients often suffer from a number of cognitive difficulties, including poor memory function, poor problem-solving capacity and difficulties with attention and concentration. These problems are not well addressed by current clinical treatments. Evidence from aging research strongly suggests that increased cardiovascular fitness may provide numerous cognitive benefits by promoting brain growth, particularly in the frontal lobes and the hippocampi. The current study will measure the effects of aerobic exercise on brain volumes in a population of chronic psychosis patients to determine if 1) hippocampal volumes increase in response to exercise and 2) if parallel improvements in cognitive functioning occur.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Brain Health: Effects of Exercise on Hippocampal Volume and Memory Deficits in Persons With Schizophrenia|
- Increase hippocampal volume with aerobic training in schizophrenic and healthy volunteers. [ Time Frame: Base-line, 8 and 12 weeks ] [ Designated as safety issue: No ]Hippocampal volumes will be measured from structural MRI scans. T1-weighted 3D SPGR (spoiled gradient recalled) and high-resilution T2- weighted structural images will be obtained for the purposes of volumetric assessment of the hippocampi and the whole brain
- Increases in hippocampal volumes will be positively associated with improvements in working memory performance in schizophrenia. [ Time Frame: Baseline, Week 4, 8 and 12. ] [ Designated as safety issue: No ]The Hopkins Verbal Learning Test (HVLT), will be used to assess memory function. Multiple versions of the HVLT exist (12) so practice effects will be minimized. The Rey-Osterrieth Complex Figure Test (ROCF), in which subjects are asked to reproduce a complex line drawing from memory, will be used to assess attention and working memory.
Biospecimen Retention: Samples With DNA
No Biospecimens to be retained
|Study Start Date:||July 2011|
|Estimated Study Completion Date:||December 2016|
|Primary Completion Date:||June 2014 (Final data collection date for primary outcome measure)|
This is a 12-week, randomized trial with two parallel groups. Throughout the trial, subjects will be treated on their prescribed dose of medication. Once informed consent is obtained, subjects and healthy volunteers will be randomly assigned to either an aerobic or a resistance exercise program (N = 24 per diagnostic group in each of two exercise conditions). Patients will continue to receive their antipsychotics and other prescribed medications. Healthy volunteer data will be used to establish normal exercise-induced neuroplasticity in a non-psychiatric, non-medicated population. All training will be conducted at the Riverview Hospital fitness facilities and at dedicated exercise training facilities at the University of British Columbia. All exercise sessions will be monitored by trained research assistants (RAs) under the guidance of the Canadian Society for Exercise Physiology-Certified Exercise Physiologists (CSEP-CEPs). The RAs will receive pre-study exercise training from the CSEP-CEPs. During the course of the study, the training intensity will be changed according to the individual participant's response and needs via the CSEP-CEPs and RAs.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01392885
|Canada, British Columbia|
|Vancouver, British Columbia, Canada, V6T 1Z3|
|Principal Investigator:||Donna J Lang, PhD||University of British Columbia, Dept. of Radiology|
|Study Chair:||William G Honer, Professor||University of British Columbia, Dept of Psychiatry|
|Study Chair:||Allen Thornton, Unspecified||Simon Fraser University|
|Study Chair:||Darren Warburton, Ass. Prof||University of British Columbia, Dept. of Human Kinetics|
|Study Chair:||Alexandra T Vertinsky, Clin. Instr.||University of British Columbia, Dept. of Radiology|
|Study Chair:||Sean Flynn, Ass. Prof.||University of British Columbia, Dept. of Psychiatry|
|Study Chair:||Alexander Rauscher, Ass. Prof.||University of British Columbia, Dept. of Radiology|
|Study Chair:||Geoffrey N Smith, Ass. Prof||University of British Columbia, Dept. of Psychiatry|