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Epigenetics of Posttraumatic Stress Disorder and Somatoform Disorders in the Course of Psychotherapy (TREPS)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2011 by Hannover Medical School.
Recruitment status was:  Recruiting
Information provided by:
Hannover Medical School Identifier:
First received: July 8, 2011
Last updated: July 11, 2011
Last verified: June 2011

This reported observational clinical study aims at identifying epigenetic markers in a sample of patients undergoing high dose inpatient psychotherapy suffering from a variety of psychiatric/psychosomatic diseases such as somatoform disorders, posttraumatic stress disorder (PTSD), depression, anxiety disorders and eating disorders.

The exact epigenetic markers that will be traced are yet to define.

The investigators believe that

  1. Epigenetic patterns found in the group of psychiatric patients show differences from healthy controls
  2. Different diagnosis show differences in epigenetic patterns as well
  3. Epigenetic patterns correlate to the severity of the psychosocial disorder as measured in interviews or psychometric ratings
  4. Epigenetic patterns can change under inpatient high dose psychotherapy
  5. Changes correlate to clinical psychometric variables.

Condition Intervention
Psychiatric Disorder Somatoform Disorders PTSD Behavioral: psychotherapy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Further study details as provided by Hannover Medical School:

Biospecimen Retention:   Samples With DNA
whole blood

Estimated Enrollment: 300
Study Start Date: January 2011
Estimated Study Completion Date: September 2012
Estimated Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
in- and out-patient psychotherapy patients
All included patients are highly selected in- and outpatients in a department of psychosomatic medicine (Germany) undergoing high dose psychotherapy (e.g. group therapy, creative therapy, cbt and psychodynamic psychotherapy).
Behavioral: psychotherapy
"multimodal complex psychotherapy"
Other Name: all patients in the department are primarily included. There are no parallel groups.


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

The present study includes all patients selected for multi-modal inpatient or day-clinic treatment in the department of psychosomatic medicine (as part of the centre of psychiatry)of the hannover medical school - given the informed consent of the patients. The patients treated in this unit are first seen in primary care and sent to us because of e.g. depression, somatization, eating-disorders, panic disorders, PTSD, or other psychiatric diseases commonly refered to as "psychosomatic" in Germany. They are subject to at least 2 diagnostic sessions in which further treamtment options are assessed.

For about one third of the patients with grave psychiatric disorders, intensive "multimodal" psychotherapy in an inpatient or day-clinic setting is recommended.


Inclusion Criteria:

  • informed consent given by the patient
  • adulthood to 65 years
  • stabel physical health
  • at least fluent in German language (as it is a group-therapy)

Exclusion Criteria:

  • psychiatric disorder such as substance addiction, psychosis, schizophrenia.
  • insufficient understanding of the terms and conditions of the study
  • insufficient emotional stability to fill out the psychometric forms required for the study.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01391897

HannoverMS Recruiting
Hannover, Lower Saxony, Germany, 30625
Contact: Stefan M Henniger, MD    49 511 532 ext 6446   
Contact: Frieling, Prof.    49 511 532 ext 6840   
Sponsors and Collaborators
Hannover Medical School
  More Information

Responsible Party: Stefan Martin Henniger, MD., Department of Psychosomatic Medicin and Psychotherapy, Hannover Medical School, Hannover, Germany Identifier: NCT01391897     History of Changes
Other Study ID Numbers: MHH-EK-5689
Study First Received: July 8, 2011
Last Updated: July 11, 2011

Keywords provided by Hannover Medical School:
somatoform disorders

Additional relevant MeSH terms:
Mental Disorders
Problem Behavior
Somatoform Disorders
Pathologic Processes
Behavioral Symptoms processed this record on September 25, 2017