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Prevalence Of Hyperhomocysteinemia In Thai Chronic Kidney Disease (CKD) Patients

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ClinicalTrials.gov Identifier: NCT01391416
Recruitment Status : Completed
First Posted : July 12, 2011
Last Update Posted : July 12, 2011
Sponsor:
Information provided by:
Bangkok Metropolitan Administration Medical College and Vajira Hospital

Brief Summary:
It is well recognized that patients with chronic kidney disease (CKD) have an increased risk for cardiovascular disease (CVD) and hyperhomocysteinemia appears to be a predictor of future CVD events. Hyperhomocysteinemia has been reported to bo of high prevalence in patients with CKD. The investigators aim to study the prevalence of hyperhomocysteinemia in Thai CKD patients by using Thai Screening and Early Evaluation of Kidney Disease (SEEK) study database and their relationship to CVD.

Condition or disease
Cardiovascular Disease Hyperhomocysteinemia

Detailed Description:
Ninety eight subjects were sampling from Thai SEEK study database Traditional Traditional risk factors of CVD such as total cholesterol, triglyceride, age, sex, history of smoking and blood pressure levels were examined and recorded. Stored sera of these subjects were analyzed for the total homocysteine (tHcy) level. Analysis of variance was used to evaluate the different of mean tHcy among groups

Study Type : Observational
Actual Enrollment : 98 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Prevalence Of Hyperhomocysteinemia In Thai CKD Patients And Relationship To Cardiovascular Events: Subgroup Analysis From Thai SEEK Study
Study Start Date : June 2010
Actual Primary Completion Date : November 2010
Actual Study Completion Date : January 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Kidney Diseases

Group/Cohort
CKD stage 3-4
CKD stage 3-4 from Thai SEEK study
hyperhomocysteine group
CKD stage 3-4 from Thai SEEK study



Primary Outcome Measures :
  1. Level of Homocysteine [ Time Frame: 3 months ]
    Level of homocysteinemia according to each CKD level


Secondary Outcome Measures :
  1. Association of cardiovascular event to the level of homocysteine [ Time Frame: 3 months ]
    Hugh level of homocysteine will have association with cardiovascular events or not


Biospecimen Retention:   Samples Without DNA
serum


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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Ninety eight subjects from CKD stages 3-4 were randomly sampling from Thai- SEEK study database. Thai-SEEK study is a community-based cross-sectional survey that was conducted between August 2007-june 2008 in four regions of Thailand (i.e Northern, Northeastern, Central and Southern) and Bangkok (Metropolitan).
Criteria

Inclusion Criteria:

  • CKD stages 3-4 from Thai SEEK Study

Exclusion Criteria:

  • CKD stage 5

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01391416


Sponsors and Collaborators
Bangkok Metropolitan Administration Medical College and Vajira Hospital
Investigators
Principal Investigator: Thananda Trakarnvanich, M.D. Renal Unit,Department of Medicine,Faculty of Medicine,Vajira Hospital,University of Bangkok Metropolis

Additional Information:
Publications:
Responsible Party: Thananda Trakarnvanich, Renal Unit,Department of Medicine,Faculty of Medicine,Vajira Hospital
ClinicalTrials.gov Identifier: NCT01391416     History of Changes
Other Study ID Numbers: VJR-0002
First Posted: July 12, 2011    Key Record Dates
Last Update Posted: July 12, 2011
Last Verified: May 2010

Keywords provided by Bangkok Metropolitan Administration Medical College and Vajira Hospital:
Hyperhomocysteinemia
Chronic kidney disease

Additional relevant MeSH terms:
Cardiovascular Diseases
Kidney Diseases
Renal Insufficiency, Chronic
Hyperhomocysteinemia
Urologic Diseases
Renal Insufficiency
Amino Acid Metabolism, Inborn Errors
Metabolism, Inborn Errors
Genetic Diseases, Inborn
Malabsorption Syndromes
Metabolic Diseases
Vitamin B Deficiency
Avitaminosis
Deficiency Diseases
Malnutrition
Nutrition Disorders