Appetite Regulation by Human Chemosignals From Tears and Plasma
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|ClinicalTrials.gov Identifier: NCT01389869|
Recruitment Status : Completed
First Posted : July 8, 2011
Last Update Posted : December 9, 2013
|Condition or disease||Intervention/treatment||Phase|
|Obesity||Biological: Sniffing emotional tears Biological: Sniffing trickled saline Biological: Sniffing fasting plasma Biological: Sniffing postprandial plasma||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||22 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Study Start Date :||June 2011|
|Actual Primary Completion Date :||December 2011|
|Actual Study Completion Date :||January 2012|
Emotional tears of female volunteers while watching sad video clips
Biological: Sniffing emotional tears
A band-aid soaked 100μl of emotional tears will be applied just below nostrils.
Other Name: Emotional tears
Placebo Comparator: Saline
Saline collected after being trickled down women's skin below eyes like tears
Biological: Sniffing trickled saline
A band-aid soaked 100μl of trickled saline will be applied just below nostrils.
Other Name: Trickled saline
Placebo Comparator: Fasting
Their own overnight fasting plasma of male volunteers
Biological: Sniffing fasting plasma
A band-aid soaked 100μl of own fasting plasma will be applied just below nostrils.
Other Name: Fasting plasma
Their own postprandial plasma of male volunteers
Biological: Sniffing postprandial plasma
A band-aid soaked 100μl of own postprandial plasma will be applied just below nostrils.
Other Name: Postprandial plasma
- The degree of appetite by visual analogue scale (VAS) and the amount of food intake by standard test meals in male volunteers while sniffing tears, trickled saline (control), and postprandial and fasting plasma in random order. [ Time Frame: Visual analogue scale (VAS) will be rated 10 minutes after initial sniffing of tears/plasma just before eating standard test meals. The amount of food intake will be measured by weighing the meals before and after eating. ]
- Appetite regulating hormones(ghrelin, GLP-1, PYY), glucose, testosterone. Determination of tears, tickled saline, and plasma. [ Time Frame: Blood samples for measuring appetite regulating hormones, glucose, testosterone will be collected at -10, 0, and 60 min. ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01389869
|Korea, Republic of|
|Seoul National University Hospital|
|Seoul, Korea, Republic of, 110-744|
|Study Chair:||Young Min Cho, MD, PHD||Seoul National University College of Medicine|