We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Appetite Regulation by Human Chemosignals From Tears and Plasma

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01389869
First Posted: July 8, 2011
Last Update Posted: December 9, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Young Min Cho, Seoul National University Hospital
  Purpose
Obesity is closely related to metabolic diseases and its prevalence is sharply increasing. However, there is no safe and effective treatment for obesity so far, the investigators need a breakthrough idea to curtail the constant threat of obesity. It has been recently demonstrated that emotional tears of women can modify sexual responses, one of basic instincts, in men. As appetite and food intake is another basic instinct, chemosignals from tears and plasma may modify appetite and eating behavior in humans.

Condition Intervention
Obesity Biological: Sniffing emotional tears Biological: Sniffing trickled saline Biological: Sniffing fasting plasma Biological: Sniffing postprandial plasma

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)

Resource links provided by NLM:


Further study details as provided by Young Min Cho, Seoul National University Hospital:

Primary Outcome Measures:
  • The degree of appetite by visual analogue scale (VAS) and the amount of food intake by standard test meals in male volunteers while sniffing tears, trickled saline (control), and postprandial and fasting plasma in random order. [ Time Frame: Visual analogue scale (VAS) will be rated 10 minutes after initial sniffing of tears/plasma just before eating standard test meals. The amount of food intake will be measured by weighing the meals before and after eating. ]

Secondary Outcome Measures:
  • Appetite regulating hormones(ghrelin, GLP-1, PYY), glucose, testosterone. Determination of tears, tickled saline, and plasma. [ Time Frame: Blood samples for measuring appetite regulating hormones, glucose, testosterone will be collected at -10, 0, and 60 min. ]

Enrollment: 22
Study Start Date: June 2011
Study Completion Date: January 2012
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Tears
Emotional tears of female volunteers while watching sad video clips
Biological: Sniffing emotional tears
A band-aid soaked 100μl of emotional tears will be applied just below nostrils.
Other Name: Emotional tears
Placebo Comparator: Saline
Saline collected after being trickled down women's skin below eyes like tears
Biological: Sniffing trickled saline
A band-aid soaked 100μl of trickled saline will be applied just below nostrils.
Other Name: Trickled saline
Placebo Comparator: Fasting
Their own overnight fasting plasma of male volunteers
Biological: Sniffing fasting plasma
A band-aid soaked 100μl of own fasting plasma will be applied just below nostrils.
Other Name: Fasting plasma
Experimental: Prandial
Their own postprandial plasma of male volunteers
Biological: Sniffing postprandial plasma
A band-aid soaked 100μl of own postprandial plasma will be applied just below nostrils.
Other Name: Postprandial plasma

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Woman: Negative for HIV, Syphilis (VDRL), and Hepatitis B and C
  • Man: Has a body mass index (BMI) of 18.5 kg/m2 to 27 kg/m2, inclusive.

Exclusion Criteria:

  • Woman: Has eyelids inflammation, conjunctivitis, keratitis, lacrimal duct obstruction. Has skin diseases around eyes.
  • Man: Has diabetes mellitus or dyslipidemia on medication. Received gastrointestinal surgery except appendectomy and hemorrhoidectomy.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01389869


Locations
Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of, 110-744
Sponsors and Collaborators
Seoul National University Hospital
Investigators
Study Chair: Young Min Cho, MD, PHD Seoul National University College of Medicine
  More Information

Responsible Party: Young Min Cho, Seoul National University, Seoul National University Hospital
ClinicalTrials.gov Identifier: NCT01389869     History of Changes
Other Study ID Numbers: H-1105-011-360
First Submitted: July 6, 2011
First Posted: July 8, 2011
Last Update Posted: December 9, 2013
Last Verified: December 2013

Keywords provided by Young Min Cho, Seoul National University Hospital:
Emotional tears
Postprandial plasma
Chemosignal
Obesity
Appetite
Food intake