MgSO4 Combined With Rocuronium Priming
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ClinicalTrials.gov Identifier: NCT01389791 |
Recruitment Status
: Unknown
Verified January 2012 by Kim Mihyun, Seoul National University Bundang Hospital.
Recruitment status was: Recruiting
First Posted
: July 8, 2011
Last Update Posted
: January 10, 2012
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Condition or disease | Intervention/treatment | Phase |
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Muscle Relaxation | Drug: magnesium sulfate Drug: priming Drug: magnesium sulfate and priming | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 100 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | MgSO4 Combined With Rocuronium Priming |
Study Start Date : | May 2011 |
Estimated Primary Completion Date : | January 2012 |
Estimated Study Completion Date : | January 2012 |
Arm | Intervention/treatment |
---|---|
No Intervention: Roc
Patients in this group receive neither MgSO4 nor priming dose of rocuronium.
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Active Comparator: priming
patients in this group receive 0.06mg/kg of rocuronium before 0.54mg/kg of rocuronium.
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Drug: priming
Patients in this group receive 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.
Other Name: rocuronium-priming
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Experimental: Mg&priming
Patients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.
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Drug: magnesium sulfate and priming
Patients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.
Other Name: MgSO4 & priming
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Active Comparator: MgSO4
Patients in this group receive intravenous MgSO4 before administration of rocuronium.
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Drug: magnesium sulfate
Patients in this group receive intravenous MgSO4 50mg/kg before administration of rocuronium (induction dose).
Other Name: MgSO4
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- time from injection of induction dose of rocuronium until 95% depression of TOF [ Time Frame: time from injection of induction dose of rocuronium until 95% depression of TOF, upto 5 min ]
- rocuronium duration [ Time Frame: time from injection of induction dose of rocuronium until train-of-four count reaches two. ]time from injection of induction dose of rocuronium until train-of-four count reaches two.
- intubating condition [ Time Frame: time from injection of induction dose of rocuronium until tracheal intubation. ]rapid sesequence intubation condition is evaluated.

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Ages Eligible for Study: | 18 Years to 65 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- patients of ASA Ⅰ-Ⅱ
- aged 18~65
- scheduled to undergo elective surgery under general anesthesia
Exclusion Criteria:
- risk of pulmonary aspiration
- anticipated airway difficulty
- reactive airway disease
- allergic to study drugs
- neuromuscular / cardiovascular/ renal/ hepatic disease
- atrioventricular conduction disturbance
- BMI < 18.5 or > 24.9
- chronic treatment with calcium channel blocker
- medications which affect muscle relaxation

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01389791
Contact: Mihyun Kim, MD | 82-31-787-2034 | snmd56@yahoo.com |
Korea, Republic of | |
Seoul national university Bundang hospital | Recruiting |
Seongnam, Kyoung-ki-do, Korea, Republic of, 463-707 |
Study Chair: | Sanghwan Do, M.D., PH.D. | Seoul National University Bundang Hospital |
Responsible Party: | Kim Mihyun, full instructor, Seoul National University Bundang Hospital |
ClinicalTrials.gov Identifier: | NCT01389791 History of Changes |
Other Study ID Numbers: |
Mg priming |
First Posted: | July 8, 2011 Key Record Dates |
Last Update Posted: | January 10, 2012 |
Last Verified: | January 2012 |
Keywords provided by Kim Mihyun, Seoul National University Bundang Hospital:
muscle relaxation magnesium sulfate rocuronium |
Additional relevant MeSH terms:
Rocuronium Magnesium Sulfate Neuromuscular Nondepolarizing Agents Neuromuscular Blocking Agents Neuromuscular Agents Peripheral Nervous System Agents Physiological Effects of Drugs Analgesics Sensory System Agents |
Anesthetics Central Nervous System Depressants Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Tocolytic Agents Reproductive Control Agents |