Functional MRI and MRA in Migraine With Aura

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01388894
Recruitment Status : Unknown
Verified May 2011 by Glostrup University Hospital, Copenhagen.
Recruitment status was:  Recruiting
First Posted : July 7, 2011
Last Update Posted : July 7, 2011
Information provided by:
Glostrup University Hospital, Copenhagen

Brief Summary:
Patients who report that exposure to bright light or strenuous physical activity will induce migraine aura will be provoked using one or both of these methods. Followingly the patients will be examined by functional MRI. Íf the patients develop migraine headache, MR angiography will be performed as well. The primary study hypothesis is that the functional MRI signal will show features similar to those of the electrophysiological phenomenon of cortical spreading depression.

Condition or disease
Migraine With Aura

Study Type : Observational
Estimated Enrollment : 80 participants
Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Functional MRI and MRA in Migraine With Aura
Study Start Date : December 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Migraine
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients diagnosed with migraine with aura

Inclusion Criteria:

  • Diagnosed with migraine with aura as defined by The International Classification of Headache Disorders 2
  • Age between 18 and 80 years both inclusive
  • Reports that bright light or strenuous physical activity may trigger migraine aura

Exclusion Criteria:

  • Contraindications towards exposure to photostimulation or strenuous exercise
  • Body weight above 130 kg
  • Pregnant or lactating females
  • Contraindications towards MRI scanning
  • History or clinical signs of: cardiovascular disease, psychiatric disease, substance abuse or any symptom or disease considered relevant by the examining physician.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01388894

Contact: Anders Hougaard, MD +4538632713

Danish Headache Center Recruiting
Glostrup, Denmark, 2600
Contact: Anders Hougaard, MD    +4538632713   
Sub-Investigator: Anders Hougaard, MD         
Sponsors and Collaborators
Glostrup University Hospital, Copenhagen

Responsible Party: Jes Olesen, Danish Headache Center Identifier: NCT01388894     History of Changes
Other Study ID Numbers: MA-01
First Posted: July 7, 2011    Key Record Dates
Last Update Posted: July 7, 2011
Last Verified: May 2011

Additional relevant MeSH terms:
Migraine Disorders
Migraine with Aura
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases