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Functional MRI and MRA in Migraine With Aura

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2011 by Glostrup University Hospital, Copenhagen.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01388894
First Posted: July 7, 2011
Last Update Posted: July 7, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Glostrup University Hospital, Copenhagen
  Purpose
Patients who report that exposure to bright light or strenuous physical activity will induce migraine aura will be provoked using one or both of these methods. Followingly the patients will be examined by functional MRI. Íf the patients develop migraine headache, MR angiography will be performed as well. The primary study hypothesis is that the functional MRI signal will show features similar to those of the electrophysiological phenomenon of cortical spreading depression.

Condition
Migraine With Aura

Study Type: Observational
Study Design: Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Functional MRI and MRA in Migraine With Aura

Resource links provided by NLM:


Further study details as provided by Glostrup University Hospital, Copenhagen:

Estimated Enrollment: 80
Study Start Date: December 2010
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients diagnosed with migraine with aura
Criteria

Inclusion Criteria:

  • Diagnosed with migraine with aura as defined by The International Classification of Headache Disorders 2
  • Age between 18 and 80 years both inclusive
  • Reports that bright light or strenuous physical activity may trigger migraine aura

Exclusion Criteria:

  • Contraindications towards exposure to photostimulation or strenuous exercise
  • Body weight above 130 kg
  • Pregnant or lactating females
  • Contraindications towards MRI scanning
  • History or clinical signs of: cardiovascular disease, psychiatric disease, substance abuse or any symptom or disease considered relevant by the examining physician.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01388894


Contacts
Contact: Anders Hougaard, MD +4538632713 andhou05@glo.regionh.dk

Locations
Denmark
Danish Headache Center Recruiting
Glostrup, Denmark, 2600
Contact: Anders Hougaard, MD    +4538632713    andhou05@glo.regionh.dk   
Sub-Investigator: Anders Hougaard, MD         
Sponsors and Collaborators
Glostrup University Hospital, Copenhagen
  More Information

Responsible Party: Jes Olesen, Danish Headache Center
ClinicalTrials.gov Identifier: NCT01388894     History of Changes
Other Study ID Numbers: MA-01
First Submitted: July 5, 2011
First Posted: July 7, 2011
Last Update Posted: July 7, 2011
Last Verified: May 2011

Additional relevant MeSH terms:
Migraine Disorders
Migraine with Aura
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases