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The Detection and Factors of Brown Adipose Tissue in Different Locations of Adults

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2010 by Huashan Hospital.
Recruitment status was:  Active, not recruiting
Information provided by:
Huashan Hospital Identifier:
First received: June 30, 2011
Last updated: July 1, 2011
Last verified: April 2010
Retrospective studies have combined positron-emission tomography and computed tomography (PET-CT) to identify adipose tissue with a high rate of uptake of 18F-fluorodeoxyglucose(18F-FDG) as active brown adipose tissue(BAT). In addition, biopsy specimens and immunohistochemical staining with a UCP1-specific antiserum were used to indicate that normal adults were able to have BAT. However,these studies only chose few subjects and limited to the neck tissue. Therefore, the investigators intend to test BAT in different parts of adults and analyse the clinical factors.


Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Cross Sectional Study on the Detection and Factors of Brown Adipose Tissue in Different Locations of Adults

Further study details as provided by Huashan Hospital:

Biospecimen Retention:   Samples Without DNA
Adipose tissue, plasma

Estimated Enrollment: 30
Study Start Date: October 2010
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Detailed Description:
The investigators will promote the cross-sectional study from 2010 to 2013 in Shanghai. Data on demographic statistics, medical history,physical examination and fasting blood sample will be collected for all patients. Adipose tissue of adults will be collected from different regions, such as cervical, perirenal, along the large blood vessels and trachea, because they are included in the range of surgical therapy and are the major locations of BAT. Adipose tissue samples will be used to immunohistochemical stain, to detect the expression of BAT related genes.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Subjects who underwent surgical therapy from 2010 to 2013 in Huashan Hospital and the operation scope includes brown adipose tissue sample sites.

Inclusion Criteria:

  • Subjects who underwent surgical therapy and the operation scope includes BAT sample sites.

Exclusion Criteria:

  • Pregnant women
  • With implantable medical electronic instrument
  • Younger than 18 years
  Contacts and Locations
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Please refer to this study by its identifier: NCT01387451

China, Shanghai
Huashan Hospital
Shanghai, Shanghai, China, 200040
Sponsors and Collaborators
Huashan Hospital
Study Chair: Yiming Li, Doctor Huashan Hospital
  More Information

Responsible Party: Yiming Li, huashan Hospital Identifier: NCT01387451     History of Changes
Other Study ID Numbers: KY2010-115
Study First Received: June 30, 2011
Last Updated: July 1, 2011

Keywords provided by Huashan Hospital:
Brown adipose tissue
Different regions
Chinese adults processed this record on June 26, 2017