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A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2011 by Baskent University.
Recruitment status was:  Recruiting
Information provided by:
Baskent University Identifier:
First received: June 21, 2011
Last updated: June 30, 2011
Last verified: June 2011
The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents regarding their effect on adrenal gland steroid synthesis in these patients.

Condition Intervention Phase
Coronary Artery Bypass Surgery Drug: Ketamine Drug: Etomidate Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Baskent University:

Primary Outcome Measures:
  • A more than 15% change in mean arterial pressure and heart rate after anesthesia induction [ Time Frame: For 60 minutes after anesthesia induction ]

Secondary Outcome Measures:
  • Adrenal gland steroid synthesis suppression [ Time Frame: 24 hours and 5 days after study drug administration ]
    A less than 9 microgram/dl increase in serum cortisol after stimulation with adrenocorticotropic hormone

Estimated Enrollment: 40
Study Start Date: March 2011
Estimated Study Completion Date: March 2012
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Ketamine Drug: Ketamine
During standard anesthesia induction with fentanyl and midazolam, ketamine 2 mg/kg IV will be administered
Active Comparator: Etomidate Drug: Etomidate
During standard anesthesia induction with fentanyl and midazolam, etomidate 3 mg/kg IV will be administered


Ages Eligible for Study:   30 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients scheduled for elective coronary artery bypass graft surgery with cardiopulmonary bypass
  • Patient's written informed consent for study participation
  • Ejection fraction ≥ 35%

Exclusion Criteria:

  • Allergy to study drugs
  • Redo surgery
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01386229

Contact: Özgür Kömürcü +90 312 215 99 41
Contact: Arash Pirat +90 312 212 68 68 ext 1800

Baskent University, Faculty of Medicine Recruiting
Ankara, Çankaya, Turkey, 06490
Sponsors and Collaborators
Baskent University
Principal Investigator: Özgür Kömürcü Baskent University, Faculty of Medicine
  More Information

Responsible Party: Özgür Kömürcü, Baskent University, Faculty of Medicine Identifier: NCT01386229     History of Changes
Other Study ID Numbers: KA-10-114
Study First Received: June 21, 2011
Last Updated: June 30, 2011

Keywords provided by Baskent University:
hemodynamic stability
coronary artery bypass surgery after induction of anesthesia, hemodynamic stability

Additional relevant MeSH terms:
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Anesthetics, Dissociative
Anesthetics, Intravenous
Anesthetics, General
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Hypnotics and Sedatives processed this record on August 18, 2017