Environmental Pollutants Relating to Human Subfertility
Environmental pollutants might be jointly responsible for increase of infertility among women. Especially endocrin active substances seem to be of particular importance. These substances are chemicals which interfere with the physiological system of humans and animals. They have a negative impact on the endocrine system and disturb the functions of organs whose hormones regulate the male and female reproductive system.
It is known that exposition to these chemicals lead to subfertility, infertility, raised abortions, birth defects and ovarian malfunction.
Additionally it was shown that human embryos have a decreased cleavage rate after IVF when developing from oocytes with elevated concentrations of environmental pollutants.
In this study the main focus concentrates on Nonylphenols (NP). Follicular fluids of women with subfertility will be analyzed by a newly developed principle including HPLC and NMR-Spectroscopy. This enables quantitative and qualitative analysis of enantiomers of NP.
The results will allow risk estimations for several endocrine active substances, especially NP.
Additionally conclusions concerning the correlation between thes substances and subfertility can be drawn.
Environmental Pollutants in Follicular Fluids
|Official Title:||Analysis of Environmental Pollutants in Follicular Fluid of Women With Subfertility|
- Pregnancy [ Time Frame: 14 days after ICSI treatment ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||September 2010|
|Study Completion Date:||March 2015|
|Primary Completion Date:||March 2015 (Final data collection date for primary outcome measure)|
ICSI treatment because of male subfertility
Please refer to this study by its ClinicalTrials.gov identifier: NCT01385605
|Infertility treatment center Dortmund|
|Dortmund, NRW, Germany, 44135|
|Principal Investigator:||Stefan Dieterle||Infertility Treatment Center Dortmund|