Stress Echocardiography and Heart Computed Tomography (CT) Scan in Emergency Department Patients With Chest Pain
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01384448 |
Recruitment Status
:
Completed
First Posted
: June 29, 2011
Last Update Posted
: March 22, 2017
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Chest Pain Angina Angina Pectoris Coronary Artery Disease | Procedure: Stress Echocardiography Procedure: Coronary CT Angiography | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 400 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Diagnostic |
Official Title: | A Randomized Trial Comparing Coronary CT Angiography and Stress Echocardiography for Evaluation of Low-to-Intermediate Risk Emergency Department Chest Pain Patients |
Study Start Date : | August 2011 |
Actual Primary Completion Date : | February 2016 |
Actual Study Completion Date : | February 2017 |

Arm | Intervention/treatment |
---|---|
Experimental: Initial Stress Echocardiography |
Procedure: Stress Echocardiography
Stress echocardiography will be performed once. Treadmill stress is default. Patients that cannot exercise will receive dobutamine stress with or without atropine. Definity intravenous contrast will be given when needed.
Other Names:
|
Experimental: Initial Coronary CT Angiography |
Procedure: Coronary CT Angiography
64-detector, resting EKG-gated coronary CT angiography will be performed once. Patients with elevated heart rates will be given oral and/or intravenous metoprolol. Prospective gating with reduced tube current will be default. Retrospective gating with tube current modulation will be used in patients with higher heart rates.
Other Names:
|
- Hospital admission [ Time Frame: 30 days ]
- Emergency Department length of stay [ Time Frame: 30 days ]
- Hospital length of stay [ Time Frame: 30 days ]
- Estimated cost of initial care [ Time Frame: 30 days ]
- Repeat visits to the Emergency Department [ Time Frame: 30 days and 1 year ]
- Death [ Time Frame: 30 days and 1 year ]
- Non-fatal myocardial infarction [ Time Frame: 30 days and 1 year ]

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 30 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Presentation to the Emergency Department with chest pain
- Low-to-intermediate risk of coronary disease per Diamond-Forrester criteria
- Free of known coronary artery disease
Exclusion Criteria:
- Inability to undergo both stress echo or coronary CT for any reason
- Contraindication to intravenous iodinated contrast
- Dysrhythmia precluding EKG gating
- Heart rate greater than 60 with contraindication to beta blockers
- Administration of beta blockers within the last 12 hours
- Known severe cardiac valvular disease or pulmonary hypertension
- Stress echocardiography, coronary CT or catheterization within the last 6 months

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01384448
United States, New York | |
Montefiore Medical Center - Weiler / Einstein Division | |
Bronx, New York, United States, 10462 |
Principal Investigator: | Jeffrey M Levsky, MD, PhD | Montefiore Medical Center / Albert Einstein College of Medicine |
Publications:
Responsible Party: | Jeffrey Levsky, Associate Director of Research, Department of Radiology, Montefiore Medical Center |
ClinicalTrials.gov Identifier: | NCT01384448 History of Changes |
Other Study ID Numbers: |
MMC-11-03-107 11SDG7380006 ( Other Grant/Funding Number: American Heart Association National Center ) |
First Posted: | June 29, 2011 Key Record Dates |
Last Update Posted: | March 22, 2017 |
Last Verified: | March 2017 |
Keywords provided by Jeffrey Levsky, Montefiore Medical Center:
stress echocardiography coronary ct angiography |
Additional relevant MeSH terms:
Coronary Artery Disease Myocardial Ischemia Coronary Disease Emergencies Angina Pectoris Chest Pain Heart Diseases Cardiovascular Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases Disease Attributes Pathologic Processes Pain Neurologic Manifestations |
Nervous System Diseases Signs and Symptoms Dobutamine Cardiotonic Agents Sympathomimetics Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Adrenergic beta-1 Receptor Agonists Adrenergic beta-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Protective Agents |