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The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2011 by Meir Medical Center.
Recruitment status was:  Active, not recruiting
Information provided by:
Meir Medical Center Identifier:
First received: June 27, 2011
Last updated: NA
Last verified: June 2011
History: No changes posted

The telomere system stabilizes the chromosomes. Telomeres are shortened during senescence, in cases of genetic instability and secondary to stress.

The investigators aim is to study the telomere system in cord blood and in the placenta immediately after the delivery in pregnancies defined as high risk pregnancies following sterss events such as placental insufficiency, preeclampsia, diabetes.

The investigators intend to compare the telomere system in maternal blood to cord blood and to placental biopsies and to study the influence of different stressogenes on this system.

Telomere Length
Mechanisms of Telomter Homeostasis
High Risk Pregnancies

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

Further study details as provided by Meir Medical Center:

Estimated Enrollment: 100
Study Start Date: June 2011
Estimated Study Completion Date: June 2015
Estimated Primary Completion Date: June 2015 (Final data collection date for primary outcome measure)
High risk pregnancy
|Control - Normal low risk pregnancies


Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
High risk pregnancies, third trimester, after the delivery/

Inclusion Criteria:

  • Third trimester post delivery
  • Intrauterine growth restriction
  • Preeclampsia
  • Diabetes
  • Control - low risk normal pregnancies

Exclusion Criteria:

  • Patients who do not want to participate
  • Known HIV or Hepatitis
  Contacts and Locations
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Please refer to this study by its identifier: NCT01384136

Meir Medical Center
Kfar Saba, Israel
Sponsors and Collaborators
Meir Medical Center
  More Information

Responsible Party: Tal Biron-Shental, Meir Medical Center, Kfar Saba, Israel Identifier: NCT01384136     History of Changes
Other Study ID Numbers: 036-2011 MMC
Study First Received: June 27, 2011
Last Updated: June 27, 2011 processed this record on May 23, 2017