F-18-AV-45 Uptake, Spot Sign Presence and Cerebral Amyloid Angiopathy (CAA) in Primary Intracranial Hemorrhage (ICH)
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|ClinicalTrials.gov Identifier: NCT01382849|
Recruitment Status : Withdrawn
First Posted : June 27, 2011
Last Update Posted : November 19, 2014
Florbetapir F 18 is an experimental radioactive drug that may allow doctors to image changes in the brain using a PET (Positron Emission Tomography) scanner. The purpose of this study is to evaluate the imaging characteristics of, Florbetapir F 18 (also known as 18F-AV-45) in patients who have previously undergone bleeding in their brains. Florbetapir F 18 binds to amyloid-ß peptide (Aß) that accumulates in the brains of patients with bleeding. These accumulations are called amyloid plaques and when extensive are labeled cerebral amyloid angiopathy (CAA). Florbetapir F 18 sticks to the amyloid plaques in the brain and emits a low level of gamma rays which can be detected by a PET camera.
MRI detected microbleeds have been identified as markers of clinically silent hemorrhage from bleeding-prone vessels. Another imaging marker of vessel damage and risk of bleeding is the spot sign (SS). Finally, certain genetic signatures (ApoE genotype) have been shown to be associated with Aß deposition in the brain or predispose patients to higher risks of bleeding. This research study will explore the interactions of these factors and understand the physiology of intracerebral bleeding.
|Condition or disease|
|Cerebral Amyloid Angiopathy|
|Study Type :||Observational|
|Actual Enrollment :||0 participants|
|Observational Model:||Case Control|
|Official Title:||F-18-AV-45 Uptake, Spot Sign Presence and Cerebral Amyloid Angiopathy (CAA) in Primary Intracranial Hemorrhage (ICH)|
|Study Start Date :||August 2011|
|Estimated Primary Completion Date :||August 2012|
|Estimated Study Completion Date :||August 2012|
CAA positive microbleeders
Cerebral amyloid angiopathy (CAA) positive microbleeders
|probable CAA macrobleeders|
|CAA negative microbleeders|
- Type of Bleed [ Time Frame: 2-3 weeks ]Patients will be divided into micro- and macro- bleeders based on MRI detected microhemorhage pattern. Processing of each patient will take 2-3 weeks.
- Spot Sign Status [ Time Frame: 2-3 weeks ]They will be further subdivided by spot sign status into positive or negative.
- Amyloid uptake [ Time Frame: 2-3 weeks ]
- ApoE genotype [ Time Frame: 2-3 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01382849
|Sunnybrook Health Sciences Centre|
|Toronto, Ontario, Canada, M4N 3M5|
|Principal Investigator:||Richard Aviv||Sunnybrook Health Sciences Centre|