ClinicalTrials.gov
ClinicalTrials.gov Menu

Protocol to Obtain Blood and Bone Marrow Samples for Myeloma Research

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01382615
Recruitment Status : Terminated (Unable to fill cohort)
First Posted : June 27, 2011
Last Update Posted : April 25, 2018
Sponsor:
Information provided by (Responsible Party):
Kenneth Meehan, Dartmouth-Hitchcock Medical Center

Brief Summary:
The purpose of this study is to collect a blood or bone marrow sample from patients with multiple myeloma and from volunteers without myeloma.

Condition or disease
Multiple Myeloma

Detailed Description:
The blood and bone marrow samples will be used in the laboratory to perform focused studies on multiple myeloma.

Study Type : Observational
Actual Enrollment : 29 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Evaluation of Immune Parameters and Function in Multiple Myeloma Patients and Healthy Individuals' Blood and Marrow Samples
Study Start Date : August 2010
Actual Primary Completion Date : December 2014
Actual Study Completion Date : December 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Multiple Myeloma

Group/Cohort
Healthy Volunteers
Healthy volunteers who have agreed to have a bone marrow and/or blood harvest as part of a donation to a transplant recipient.
Patients with multiple myeloma
Patients undergoing routine blood draw and bone marrow aspirates as part of their ongoing follow-up care for myeloma at the Norris Cotton Cancer Center of DHMC.



Primary Outcome Measures :
  1. Cancer cell response to molecular testing of killing cell parts. [ Time Frame: 2 Years ]
    This myeloma specific killing may help identify mechanisms, in vitro, of killing myeloma cells for the future use in clinical trials.


Biospecimen Retention:   Samples With DNA
15mL of peripheral blood 10mL of bone marrow aspirate


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients at Dartmouth-Hitchcock Medical Center's Norris Cotton Cancer Center
Criteria

Inclusion Criteria:

  • Participant population is multiple myeloma patients over the age of 18 who are undergoing a scheduled bone marrow collection and/or blood drawing procedure as part of their routine treatment or follow up, and healthy volunteers over the age of 18 who have agreed to have a bone marrow and/or blood harvest as part of a donation to a transplant recipient.

Exclusion Criteria:

  • Patients, who in the opinion of their physician, would be adversely affected by removal of an extra15ml of blood and /or an extra 10ml of bone marrow.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01382615


Locations
United States, New Hampshire
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Sponsors and Collaborators
Dartmouth-Hitchcock Medical Center
Investigators
Principal Investigator: Kenneth Meehan, MD Dartmouth-Hitchcock Medical Center

Responsible Party: Kenneth Meehan, Director, Bone Marrow Transplant Program, Dartmouth-Hitchcock Medical Center
ClinicalTrials.gov Identifier: NCT01382615     History of Changes
Other Study ID Numbers: D1029
First Posted: June 27, 2011    Key Record Dates
Last Update Posted: April 25, 2018
Last Verified: May 2016

Keywords provided by Kenneth Meehan, Dartmouth-Hitchcock Medical Center:
Multiple Myeloma

Additional relevant MeSH terms:
Multiple Myeloma
Neoplasms, Plasma Cell
Neoplasms by Histologic Type
Neoplasms
Hemostatic Disorders
Vascular Diseases
Cardiovascular Diseases
Paraproteinemias
Blood Protein Disorders
Hematologic Diseases
Hemorrhagic Disorders
Lymphoproliferative Disorders
Immunoproliferative Disorders
Immune System Diseases