Trodat 1 SPECT and Dopamine Polymorphism
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01381302|
Recruitment Status : Completed
First Posted : June 27, 2011
Last Update Posted : February 9, 2016
The study population will include 100 parkinsonian patients in early stage of disease, with total duration not exeeding 5 years.
The patients will undergo neurologic examination and evaluation of disease severity using the unified PD rating scale. Subsequently a brain SPECT will be performed using Tc-99m-Trodat1.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||90 participants|
|Official Title:||Association of Polymorphism in Genes Associated With Control of Dopamine Levels in Parkinson's Disease and Tc-99m-Trodat-1 SPECT Imaging.|
|Study Start Date :||August 2011|
|Primary Completion Date :||August 2012|
|Study Completion Date :||August 2012|
Early onset of disease
- Disease severity versus genetic polymorphism [ Time Frame: 1 year ]Correlation of disease severity with polymorphism and with striatal affinity to the DAT ligand.
- Severity of PD compared to specific striatal DAT activity as measures by Tc-99m Trodat SPECT. [ Time Frame: 1 year ]For each striatal ROI, mean counts will be measured, and specific TRODAT uptake will be calculated, according to the following formula: Specific TRODAT uptake = (mean activity in ROI - mean Activity in occipital cortex) / mean Activity in occipital cortex).
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01381302
|Edith Wolfson medical Center|
|Holon, Israel, 58100|
|Principal Investigator:||Mordechai Lorberboym, MD||Edith Wolfson Medical Center|