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The Incidence and Factors of Brown Adipose Tissue in Chinese

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2009 by Huashan Hospital.
Recruitment status was:  Active, not recruiting
Information provided by:
Huashan Hospital Identifier:
First received: June 23, 2011
Last updated: NA
Last verified: December 2009
History: No changes posted
Previous studies have shown active brown adipose tissue (BAT) is present in adults and may play important roles in regulating energy homeostasis. However, the majorities of these studies were done in patients undergoing scanning for cancer surveillance, and may not reflect BAT behavior in healthy individuals. In addition, little is known about the ethnic variation in BAT activity, particularly in Chinese adults. Due to the large amount in our cohort, we are able to look at the difference between subjects for cancer surveillance (CS) and subjects for medical check-up (MC), and to clarify the impact of clinical and lifestyle parameters.


Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Retrospective Study on the Incidence and Factors of Brown Adipose Tissue in Adult Chinese

Further study details as provided by Huashan Hospital:

Estimated Enrollment: 600
Study Start Date: February 2010
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Detailed Description:
We will study scanning database including data from July 2006 to June 2010 in Shanghai. BAT activity will be measured via 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). Age, imaging date, sex, and outdoor temperature will be collected for all patients. To evaluate the effects of multiple metabolic parameters on BAT activity, we will collect height, body weight, fasting plasma glucose (FPG), medical history, diagnosis, smoking, alcohol consumption, exercise, liver triglyceride content, and thyroid metabolic activity for all patients with detectable BAT and their negative controls, consisting of two patients who underwent PET/CT scans at the same day but without detectable BAT.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Subjects who underwent scanning for either cancer surveillance (CS) or medical check-up (MC) from July 2006 to June 2010 in Huashan Hospital.

Inclusion Criteria:

  • Subjects with detectable brown adipose tissue
  • Negative controls, consisting of two subjects who underwent PET/CT scans at the same day but without detectable BAT

Exclusion Criteria:

  • Younger than 18 years
  Contacts and Locations
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Please refer to this study by its identifier: NCT01381042

Huashan Hospital
Shanghai, China, 200040
Sponsors and Collaborators
Huashan Hospital
Study Chair: Yiming Li, Dr. Huashan Hospital
  More Information

Responsible Party: Yiming Li, Division of Endocrinology and Metabolism Identifier: NCT01381042     History of Changes
Other Study ID Numbers: KY2009-307
Study First Received: June 23, 2011
Last Updated: June 23, 2011

Keywords provided by Huashan Hospital:
Brown Adipose Tissue
Human processed this record on September 21, 2017