Treatment of Lambert-Eaton Myasthenic Syndrome (LEMS) With 3, 4 DAP
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|ClinicalTrials.gov Identifier: NCT01378546|
Expanded Access Status : No longer available
First Posted : June 22, 2011
Last Update Posted : July 18, 2013
Lambert Eaton Myasthenic Syndrome (LEMS) is rare neurological disorder that results in muscle weakness and limited reflex activity. More than half of LEMS cases are associated with a malignancy, usually small cell lung cancer, and tend to progress more quickly than cases not coupled with malignant cells.
3,4diaminopyridine (3,4DAP)is a drug that has been demonstrated to be effective in treating the weakness associated with LEMS as it increases strength and improves autonomic symptoms in LEMS patients. It is not currently approved by the FDA for use in the United States. The investigators plan to use 3,4DAP to treat patients with LEMS here at the Columbia University MDA/ALS Research Center.
|Condition or disease||Intervention/treatment|
|Lambert Eaton Myasthenic Syndrome (LEMS)||Drug: 3,4-diaminopyridine|
|Study Type :||Expanded Access|
|Official Title:||Treatment of Lambert-Eaton Myasthenic Syndrome and Congenital Myasthenic Syndromes With 3, 4-Diaminopyridine|
|Study Start Date :||May 2005|
|Estimated Primary Completion Date :||May 2015|
- Drug: 3,4-diaminopyridine
Treatment will begin with 5mg three times a day or less.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01378546
|United States, New York|
|Columbia University Medical Center|
|New York, New York, United States, 10032|
|Principal Investigator:||Louis H Weimer, MD||Columbia University|