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Contrast Ultrasound Perfusion Imaging in Peripheral Arterial Disease (PAD)

This study has been completed.
Information provided by (Responsible Party):
Jonathan R. Lindner, MD, Oregon Health and Science University Identifier:
First received: June 20, 2011
Last updated: September 26, 2016
Last verified: September 2016
Contrast ultrasound is a technique that can quantify blood flow in the tissues of the body by ultrasound detection of microbubble contrast agents that behave in the circulation similar to red blood cells. In this study, the investigators hypothesize that contrast ultrasound of blood flow in the leg (thigh and calf) at rest and during stress produced by medications that mimic exercise (vasodilator stress) can provide information on the location and severity of peripheral vascular disease (blockages of the blood vessels in the leg). The investigators will also determine whether symptom improvement after revascularization (procedures to open up or bypass the blockages) is directly related to the improvement in blood flow.

Peripheral Arterial Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Contrast Ultrasound Perfusion Imaging in Peripheral Arterial Disease

Resource links provided by NLM:

Further study details as provided by Oregon Health and Science University:

Primary Outcome Measures:
  • Quantitation of Perfusion [ Time Frame: Immediate ]
    Correlation of skeletal muscle perfusion with symptom status

Enrollment: 18
Study Start Date: July 2011
Study Completion Date: September 2016
Primary Completion Date: September 2016 (Final data collection date for primary outcome measure)
Age matched control subjects without PAD
Patients with PAD


Ages Eligible for Study:   19 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with peripheral arterial disease who are referred for diagnostic angiography and/or revascularization procedures

Inclusion Criteria:

  1. Known or suspected PAD
  2. Lower extremity angiography or MRA planned or performed within 6 months

Exclusion Criteria:

  1. Age <19 y.o.
  2. Pregnant or lactating females
  3. Hypersensitivity to ultrasound contrast agent, dipyridamole, or regadenoson
  4. Severe reactive airways disease
  5. Evidence right-to-left shunt (identified on screening echo)
  6. NYHA Class III or IV heart failure.
  7. Planned amputation
  8. Unstable coronary artery disease or severe aortic stenosis
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Please refer to this study by its identifier: NCT01377649

United States, Oregon
Oregon Health & Science University
Portland, Oregon, United States, 97239
Sponsors and Collaborators
Oregon Health and Science University
  More Information

Responsible Party: Jonathan R. Lindner, MD, Professor, Oregon Health and Science University Identifier: NCT01377649     History of Changes
Other Study ID Numbers: IRB00007524
Study First Received: June 20, 2011
Last Updated: September 26, 2016

Additional relevant MeSH terms:
Peripheral Arterial Disease
Peripheral Vascular Diseases
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases processed this record on May 23, 2017