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Conversion Rate of (TST) Tuberculin Skin Test and Quantiferon-TB Gold In Tube Assay in Health Care Workers

This study has been completed.
Information provided by (Responsible Party):
Yonsei University Identifier:
First received: June 16, 2011
Last updated: March 4, 2013
Last verified: March 2013
The purpose of this study is to access conversion rate of TST (Tuberculin skin test) and Quantiferon-TB Gold In tube assay in health care workers.


Study Type: Observational
Study Design: Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Conversion Rate of TST and Quantiferon-TB Gold In Tube Assay in Health Care Workers

Resource links provided by NLM:

Further study details as provided by Yonsei University:

Primary Outcome Measures:
  • conversion rate of latent tuberculosis infection in hospital workers [ Time Frame: 3months ]

Biospecimen Retention:   Samples Without DNA
whole blood for perfoming Quantiferon-TB Gold in tube assay

Enrollment: 53
Study Start Date: June 2011
Study Completion Date: May 2012
Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Health care workers
health care workers who performed TST or Quantiferon-TB Gold In tube assay before


Ages Eligible for Study:   20 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
health care workers who performed TST or Quantiferon-TB Gold In tube assay before

Inclusion Criteria:

  • age 20-75, men and women
  • participant who was enrolled in the study of latent tuberculosis in health care worker (IRB No.4-2009-0187)
  • high risk or low risk health care worker who was performed TST or Quantiferon-TB Gold In tube assay before

Exclusion Criteria:

  • age < 20
  • person who don't agree with enrollment
  • illiterate
  • person who is diagnosed as active tuberculosis now
  • person who has history of hypersensitivity on PPD (tuberculin purified protein derivative)
  • pregnant woman
  • person who is treated as active tuberculosis
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Please refer to this study by its identifier: NCT01376843

Korea, Republic of
Severance Hospital
Seoul, Korea, Republic of, 120-752
Sponsors and Collaborators
Yonsei University
  More Information

Responsible Party: Yonsei University Identifier: NCT01376843     History of Changes
Other Study ID Numbers: 4-2011-0161
Study First Received: June 16, 2011
Last Updated: March 4, 2013

Keywords provided by Yonsei University:
latent tuberculosis in health care workers

Additional relevant MeSH terms:
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections processed this record on April 28, 2017