Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults
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We propose to examine a population of Native Americans who have had little or no dental care, and to determine if periodontal disease is associated with early signs of vascular dysfunction or systemic inflammation. We then propose to treat the periodontitis and re-evaluate vascular function. We will determine if gingivitis or mild/moderate periodontitis is associated with detectable vascular dysfunction. Microbial metagenomics will be correlated with vascular function.
Determination of bacterial populations in periodontal samples before and after standard periodontal treatment, stratified by severity of gum disease, using microbial metagenomics analysis. [ Time Frame: Time of enrollment and at 6 week follow up visit ]
The study will assess if periodontal bacterial flora differ in patients with healthy gums, mild, or severe periodontal disease.
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Ages Eligible for Study:
21 Years to 40 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
The study population comprises 200 Native Americans seeking health care at the Indian Health Council.
American Indian/Alaskan Natives seeking health care at the Indian Health Council, Inc.
Males and females aged 21-40 years.
Recent (within 6 months) periodontal treatment
History of high blood pressure or existing heart disease
Currently receiving treatment for cancer
Currently taking anti-inflammatory medications (except H2 blockers, statins, or medications that can affect periodontal status
Immunosuppressed due to medication or HIV infection, or presence of active infection such as hepatitis or tuberculosis
Fewer than 20 teeth in functional dentition, excluding third molars, or other gross oral pathology