Coupling of Neural Activity and Retinal Blood Flow in Diabetes
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01375166|
Recruitment Status : Recruiting
First Posted : June 17, 2011
Last Update Posted : January 9, 2018
The prevalence of diabetes is increasing and the management of the disease is nowadays considered a major challenge. Affected patients have increased mortality and morbidity as well as a significant drop in the quality of life. The complications of diabetes can be classified as microvascular (e.g. nephropathy, neuropathy or retinopathy) or macrovascular (e.g. cardiovascular or cerebrovascular).
Several large-scale epidemiologic studies indicating that wider retinal venous caliber is strongly associated with the fasting glucose level as well as with diabetes. Another retinal vascular abnormality that is associated with diabetes is an abnormal retinal vascular response to flicker stimulation. Retinal vessel dilatation in response to stimulation with diffuse flicker light occurs due to a phenomenon called neurovascular coupling. This means that increased activity of neurons is associated with an increased retinal metabolism. This leads to a release of endogenous vasodilator substances and increased blood flow. However, previous studies were limited by the fact that retinal vessel diameters and blood flow were not measured simultaneously.
The present study aims to investigate whether the response of retinal vessel diameters and blood flow velocities to flicker stimulation is altered in patients with diabetes. Both parameters will be measured in real time using Fourier Domain Doppler OCT.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||48 participants|
|Actual Study Start Date :||March 6, 2013|
|Estimated Primary Completion Date :||January 2019|
|Estimated Study Completion Date :||April 2019|
Patients with early insulin dependent diabetes and no or mild non-proliferative retinopathy
healthy control subjects
- Retinal vessel diameters [ Time Frame: 18 months ]
- Retinal blood flow velocities [ Time Frame: 18 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01375166
|Contact: Gerhard Garhöfer, MD||0043 1 40400 ext email@example.com|
|Department of Clinical Pharmacology||Recruiting|
|Vienna, Austria, 1090|
|Principal Investigator:||Gerhard Garhöfer, MD||Department of Clinical Pharmacology, Medical University of Vienna|