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The Role of Fibrocytes in Acute Lung Injury

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2011 by Taipei Medical University WanFang Hospital.
Recruitment status was:  Active, not recruiting
Information provided by:
Taipei Medical University WanFang Hospital Identifier:
First received: June 13, 2011
Last updated: NA
Last verified: June 2011
History: No changes posted
The important character of acute lung injury (ALI) is alveolar capillary membrane damage caused by different diseases, such as sepsis, trauma and shock. One of the important pathological stages is the varying degrees of interstitial fibrosis and semi-permeable alveolar membrane fibrosis. It has been proved that CXCL12/SDF-1 (stromal cell-derived factor-1) induces fibrocyte migration, and promotes fibrosis progression. Study indicated that inhibition of TLR4 receptor signaling pathway improves fibrosis progression induced by ALI, however, the role of fibrocyte in ALI is still unclear. The fibrocytes was significantly increased in asthmatic patients with pulmonary fibrosis, which companies with increased CTGF expression. Therefore, this project assumes that fibrocyte will differentiation to fibroblast/myofibroblast in patient with acute lung injury, which in turn leads to progression of fibrosis. The central hypothesis of this project is that peripheral progenitor cell fibrocytes play an important role in alveolitis caused by acute lung injury. The overall objective of this project is to study the role of fibrocytes in acute lung injury.

Acute Lung Injury(ALI)

Study Type: Observational
Study Design: Observational Model: Case-Only
Official Title: The Role of Fibrocytes in Acute Lung Injury

Resource links provided by NLM:

Further study details as provided by Taipei Medical University WanFang Hospital:

Estimated Enrollment: 20
Study Start Date: January 2011
Estimated Study Completion Date: December 2011

Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Acute Lung Injury patients

Inclusion Criteria:

  • Acute Lung Injury patients
  • Above 20 years old
  • Bilateral lung infiltrates
  • PaO2/FiO2<300mmHg
  • PCWP<18mmHg

Exclusion Criteria:

  • Pregnant women
  • Under 20 years old
  • Hb<8.0mg/dl
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Please refer to this study by its identifier: NCT01373203

Taipei Medical University - WanFang Hospital
Taipei, Taiwan
Sponsors and Collaborators
Taipei Medical University WanFang Hospital
Principal Investigator: Kuan-Jen Bai Taipei Medical University WanFang Hospital
  More Information

Responsible Party: Kuan-Jen Bai, Division of Pulmonary & Critical Care Medicine Identifier: NCT01373203     History of Changes
Other Study ID Numbers: 99077
Study First Received: June 13, 2011
Last Updated: June 13, 2011

Keywords provided by Taipei Medical University WanFang Hospital:
Acute Lung Injury(ALI)

Additional relevant MeSH terms:
Wounds and Injuries
Lung Injury
Acute Lung Injury
Respiratory Distress Syndrome, Adult
Lung Diseases
Respiratory Tract Diseases
Thoracic Injuries
Respiration Disorders processed this record on June 23, 2017