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The Role of Fibrocytes in Acute Lung Injury

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ClinicalTrials.gov Identifier: NCT01373203
Recruitment Status : Unknown
Verified June 2011 by Taipei Medical University WanFang Hospital.
Recruitment status was:  Active, not recruiting
First Posted : June 14, 2011
Last Update Posted : June 14, 2011
Sponsor:
Information provided by:
Taipei Medical University WanFang Hospital

Brief Summary:
The important character of acute lung injury (ALI) is alveolar capillary membrane damage caused by different diseases, such as sepsis, trauma and shock. One of the important pathological stages is the varying degrees of interstitial fibrosis and semi-permeable alveolar membrane fibrosis. It has been proved that CXCL12/SDF-1 (stromal cell-derived factor-1) induces fibrocyte migration, and promotes fibrosis progression. Study indicated that inhibition of TLR4 receptor signaling pathway improves fibrosis progression induced by ALI, however, the role of fibrocyte in ALI is still unclear. The fibrocytes was significantly increased in asthmatic patients with pulmonary fibrosis, which companies with increased CTGF expression. Therefore, this project assumes that fibrocyte will differentiation to fibroblast/myofibroblast in patient with acute lung injury, which in turn leads to progression of fibrosis. The central hypothesis of this project is that peripheral progenitor cell fibrocytes play an important role in alveolitis caused by acute lung injury. The overall objective of this project is to study the role of fibrocytes in acute lung injury.

Condition or disease
Acute Lung Injury(ALI)

Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Case-Only
Official Title: The Role of Fibrocytes in Acute Lung Injury
Study Start Date : January 2011
Estimated Study Completion Date : December 2011






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Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Acute Lung Injury patients
Criteria

Inclusion Criteria:

  • Acute Lung Injury patients
  • Above 20 years old
  • Bilateral lung infiltrates
  • PaO2/FiO2<300mmHg
  • PCWP<18mmHg

Exclusion Criteria:

  • Pregnant women
  • Under 20 years old
  • Hb<8.0mg/dl

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01373203


Locations
Taiwan
Taipei Medical University - WanFang Hospital
Taipei, Taiwan
Sponsors and Collaborators
Taipei Medical University WanFang Hospital
Investigators
Principal Investigator: Kuan-Jen Bai Taipei Medical University WanFang Hospital

Responsible Party: Kuan-Jen Bai, Division of Pulmonary & Critical Care Medicine
ClinicalTrials.gov Identifier: NCT01373203     History of Changes
Other Study ID Numbers: 99077
First Posted: June 14, 2011    Key Record Dates
Last Update Posted: June 14, 2011
Last Verified: June 2011

Keywords provided by Taipei Medical University WanFang Hospital:
Acute Lung Injury(ALI)

Additional relevant MeSH terms:
Wounds and Injuries
Lung Injury
Acute Lung Injury
Respiratory Distress Syndrome, Adult
Lung Diseases
Respiratory Tract Diseases
Thoracic Injuries
Respiration Disorders