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Plasma Adiponectin Concentration, Activity and Isoforms in Newly Diagnosed and Untreated Type 2 Diabetes Mellitus

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2010 by Xijing Hospital.
Recruitment status was:  Recruiting
Information provided by:
Xijing Hospital Identifier:
First received: June 11, 2011
Last updated: June 13, 2011
Last verified: May 2010
The objective of present study were to compare plasma adiponectin isoform status, their bioactivities newly diagnosed Chinese with healthy volunteer.

Diabetes Mellitus

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Plasma Adiponectin Concentration, Activity and Isoforms in Newly Diagnosed and Untreated T2DM Patients in Chinese Population

Further study details as provided by Xijing Hospital:

Primary Outcome Measures:
  • plasma adiponectin concentration, isoform distribution and activity. [ Time Frame: participants will be followed for the duration of hospital stay, an expected average of 1 week ]

Biospecimen Retention:   Samples Without DNA
blood,abdominal fat tissue

Estimated Enrollment: 300
Study Start Date: May 2010
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
T2DM patients
newly diagnosed T2DM patients and untreated with any drugs.
Non-diabetic Control Group

Detailed Description:
Adiponectin, circulates as trimer, hexamer and high molecular weight form (HMW) in human blood, is a promising biomarker for indication diabetes and cardiovascular disease. Both adiponectin complexes concentration and their bioactivities are decreased in pathological state. Disulfide-bond A oxidoreductase-like protein (DsbA-L) is a key regulator for adiponectin biosynthesis and its expression level is down-regulated in obese mice and humans. However, the alteration of circulating adiponectin multimers distribution, their bioactivities and adiponectin regulator, DsbA-L level, in newly diagnosed Chinese type 2 diabetes patients are unknown. The objective of present study were to compare plasma adiponectin isoform status, their bioactivities and DsbA-L concentration in newly diagnosed Chinese with healthy volunteer.

Ages Eligible for Study:   30 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
This study enrolls a group of 30-70years patients from primary care clinic who have diabetes history within 12 months and without taking any treatment.

Inclusion Criteria:

  • Having a diabetic history within 12 months
  • BMI smaller than 30kg/m2

Exclusion Criteria:

  • Having any kinds of treatment affecting glucose
  • pregnant
  • uncontrolled hypertension, active cardiac disease, or other major liver, kidney disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01372852

Contact: Ling Tao, M.D Ph.D +86-15002955798

China, Shaanxi
Xijing Hospital Recruiting
Xi'an, Shaanxi, China, 710032
Contact: Ling Tao, MD,PhD    +86-15002955798   
Sponsors and Collaborators
Xijing Hospital
Principal Investigator: Ling Tao, M.D Ph.D Department of Cardiology of Xijing Hospital, Fourth Military Medical University
  More Information

Responsible Party: Ling Tao, Department of Cardiology of Xijing Hospital; Fourth Military Medical University Identifier: NCT01372852     History of Changes
Other Study ID Numbers: xjyy110501
Study First Received: June 11, 2011
Last Updated: June 13, 2011

Keywords provided by Xijing Hospital:
Diabetes mellitus

Additional relevant MeSH terms:
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases processed this record on April 28, 2017