Continuous Chest Compressions vs AHA Standard CPR of 30:2 (CCC)
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ClinicalTrials.gov Identifier: NCT01372748 |
Recruitment Status :
Completed
First Posted : June 14, 2011
Results First Posted : October 5, 2016
Last Update Posted : December 28, 2016
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Out of Hospital Cardiac Arrest | Other: Standard CPR Other: Continuous chest compressions | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 23711 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | Trial Of Continuous Compressions Versus Standard CPR In Patients With Out-Of-Hospital Cardiac Arrest |
Study Start Date : | June 2011 |
Actual Primary Completion Date : | August 2015 |
Actual Study Completion Date : | November 2015 |

Arm | Intervention/treatment |
---|---|
Active Comparator: Standard CPR
American Heart Association (AHA)recommended cardiopulmonary resuscitation (CPR) of 30 compressions with brief pause for 2 ventilations
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Other: Standard CPR
30:2 CPR consists of 3 cycles of standard CPR with each cycle consisting of 30 chest compressions with a pause for 2 ventilations at a compression:ventilation ratio of 30:2. CCC consists of a series of three cycles of continuous chest compressions without pauses for ventilation. In either group, each cycle will be followed by rhythm analysis until three cycles are completed or restoration of spontaneous circulation (ROSC), whichever occurs first. |
Experimental: Continuous chest compressions
Continuous compression CPR
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Other: Continuous chest compressions
Continuous chest compressions during the first 6 minutes of the resuscitation. |
- Number of Participants Who Survive From the Time of Cardiac Arrest to Hospital Discharge [ Time Frame: Patients will be followed from the time of the cardiac arrest until death or hospital discharge, whichever occurs first. ]Patients may die in the field (outside of the hospital at the time of the cardiac arrest), at the emergency room, in the hospital, or they are discharged alive from the hospital.
- Percentage of Participants Scoring at or Below a 3 on the MRS Scale [ Time Frame: Patients will be followed from the time of the cardiac arrest until death or hospital discharge, whichever occurs first. ]Neurologic status at discharge will be assessed using the modified Rankin Score (MRS). A higher value indicates a worse outcome. 0-No symptoms at all; 1-No significant disability despite symptoms; able to carry out all usual duties and activities, 2-Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance, 3-Moderate disability; requiring some help, but able to walk without assistance; 4-Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance, 5-Severe disability; bedridden, incontinent and requiring constant nursing care and attention; 6-Dead

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Age 18 years or more (or local age of consent);
- Initial fire/Emergency Medical Services (EMS) chest compressions provided by Resuscitation Outcomes Consortium (ROC) study participating agency dispatched to the scene;
- Lack of the exclusion criteria below
Exclusion Criteria:
- EMS witnessed arrest;
- Written do not attempt resuscitation (DNAR) orders;
- Obvious primary asphyxia or respiratory cause of arrest (drowning, strangulation, hanging)
- Advanced airway placed prior to ROC EMS arrival, or pre-existing tracheostomy
- Traumatic cause (blunt, penetrating, burn) of arrest;
- Known prisoners;
- Known pregnancy;
- Uncontrolled bleeding or exsanguination
- Mechanical compression device used during study-assigned compression cycles

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01372748
United States, Alabama | |
Alabama Resuscitation Center | |
Birmingham, Alabama, United States, 35294 | |
United States, Pennsylvania | |
The Pittsburgh Resuscitation Network, University of Pittsburgh | |
Pittsburgh, Pennsylvania, United States, 15261 | |
United States, Texas | |
Dallas Center for Resuscitation Research, University of Texas Southwestern Medical Center | |
Dallas, Texas, United States, 75390 | |
United States, Washington | |
Seattle-King County Center for Resuscitation Research | |
Seattle, Washington, United States, 98195-6422 | |
United States, Wisconsin | |
Milwaukee Resuscitation Network, Medical College of Wisconsin | |
Milwaukee, Wisconsin, United States, 53226 | |
Canada, Ontario | |
University of Ottawa/University of British Columbia Collaborative RCC, Ottawa Health Research | |
Ottawa, Ontario, Canada, K1Y 4E9 | |
Rescu | |
Toronto, Ontario, Canada, M5B 1W8 |
Study Chair: | Myron Weisfeldt, MD, MD | Johns Hopkins University |
Responsible Party: | Susanne May, Principal Investigator, University of Washington |
ClinicalTrials.gov Identifier: | NCT01372748 |
Other Study ID Numbers: |
40404-B 5U01HL077863-07 ( U.S. NIH Grant/Contract ) |
First Posted: | June 14, 2011 Key Record Dates |
Results First Posted: | October 5, 2016 |
Last Update Posted: | December 28, 2016 |
Last Verified: | November 2016 |
cardiac arrest cardiopulmonary resuscitation |
Heart Arrest Out-of-Hospital Cardiac Arrest Heart Diseases Cardiovascular Diseases |