Effects of Exposure to Biomass-burning Air Pollution on Lung Function, Heart Rate Variability and Inflammatory Markers in Sugarcane Workers
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01371188 |
Recruitment Status :
Completed
First Posted : June 10, 2011
Last Update Posted : June 10, 2011
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Introduction: Non-mechanized sugar cane harvesting preceded by burning, an important and prevalent professional activity of agribusiness segment of the Brazilian economy, exposes workers and people of neighboring towns to high concentrations of pollutants and, therefore, potentially several risks to health hazards.
Objectives: Assessing cardiopulmonary impacts and inflammatory markers in sugarcane workers and volunteers from a nearby town in non-harvest and harvest periods.
Condition or disease |
---|
Lung Function Heart Rate Variability Oxidative Stress Systemic Inflammatory Response |
Study Type : | Observational |
Actual Enrollment : | 222 participants |
Observational Model: | Ecologic or Community |
Time Perspective: | Prospective |
Official Title: | Effects of Exposure to Outdoor Air Pollution From Biomass Burning on Lung Function, Heart Rate Variability and Systemic Inflammatory Blood Markers in Sugarcane Workers |
Study Start Date : | December 2008 |
Actual Primary Completion Date : | October 2010 |
Actual Study Completion Date : | February 2011 |

Group/Cohort |
---|
Controls
Healthy male volunteers, non-smokers, 20-40yo, living in the city of Mendonça, São Paulo-Brazil.
|
Sugarcane Workers
Healthy male volunteers, non-smokers, 20-40yo, sugarcane workers, living in the city of Mendonça, São Paulo-Brazil.
|
- Lung function [ Time Frame: six months ]Measurements of lung function in pre harvest and during harvest period
- Heart rate variability [ Time Frame: six months ]To evaluate parameters of heart rate variability in pre harvest and during harvest periods
- Oxidative stress [ Time Frame: six months ]Measurement of blood levels of antioxidant enzymes and malonaldehyde
- Environmental evaluation [ Time Frame: one year ]Measurement of athmospheric concentration of particulate matter.
Biospecimen Retention: Samples With DNA

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 20 Years to 40 Years (Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- The criteria for inclusion in the study were: age between 20 and 40 years, male gender and being non-smokers (or former-smokers for at least a year and a smoking history of less than 20 pack-years).
Exclusion Criteria:
- Exclusion criteria were history of cardiovascular or respiratory disease, the use of bronchodilator, non-steroidal anti-inflammatory drugs, anticoagulants or antiplatelet drugs and statins.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01371188
Brazil | |
City of Mendonça (urban area and sugarcane plantations) | |
Mendonça, Sao Paulo, Brazil, 15220-000 |
Responsible Party: | Dr Ubiratan de Paula Santos and Dr. Gustavo Faibischew Prado, InCor |
ClinicalTrials.gov Identifier: | NCT01371188 |
Other Study ID Numbers: |
Mendonca 402195/2008 ( Other Identifier: CNPQ ) |
First Posted: | June 10, 2011 Key Record Dates |
Last Update Posted: | June 10, 2011 |
Last Verified: | June 2011 |
Burns Wounds and Injuries |