Effects of Exposure to Biomass-burning Air Pollution on Lung Function, Heart Rate Variability and Inflammatory Markers in Sugarcane Workers
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|ClinicalTrials.gov Identifier: NCT01371188|
Recruitment Status : Completed
First Posted : June 10, 2011
Last Update Posted : June 10, 2011
Introduction: Non-mechanized sugar cane harvesting preceded by burning, an important and prevalent professional activity of agribusiness segment of the Brazilian economy, exposes workers and people of neighboring towns to high concentrations of pollutants and, therefore, potentially several risks to health hazards.
Objectives: Assessing cardiopulmonary impacts and inflammatory markers in sugarcane workers and volunteers from a nearby town in non-harvest and harvest periods.
|Condition or disease|
|Lung Function Heart Rate Variability Oxidative Stress Systemic Inflammatory Response|
|Study Type :||Observational|
|Actual Enrollment :||222 participants|
|Observational Model:||Ecologic or Community|
|Official Title:||Effects of Exposure to Outdoor Air Pollution From Biomass Burning on Lung Function, Heart Rate Variability and Systemic Inflammatory Blood Markers in Sugarcane Workers|
|Study Start Date :||December 2008|
|Actual Primary Completion Date :||October 2010|
|Actual Study Completion Date :||February 2011|
Healthy male volunteers, non-smokers, 20-40yo, living in the city of Mendonça, São Paulo-Brazil.
Healthy male volunteers, non-smokers, 20-40yo, sugarcane workers, living in the city of Mendonça, São Paulo-Brazil.
- Lung function [ Time Frame: six months ]Measurements of lung function in pre harvest and during harvest period
- Heart rate variability [ Time Frame: six months ]To evaluate parameters of heart rate variability in pre harvest and during harvest periods
- Oxidative stress [ Time Frame: six months ]Measurement of blood levels of antioxidant enzymes and malonaldehyde
- Environmental evaluation [ Time Frame: one year ]Measurement of athmospheric concentration of particulate matter.
Biospecimen Retention: Samples With DNA
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01371188
|City of Mendonça (urban area and sugarcane plantations)|
|Mendonça, Sao Paulo, Brazil, 15220-000|