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Molecular Profiling of Metastatic Cancer in Pleural Effusion and Ascites

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ClinicalTrials.gov Identifier: NCT01369992
Recruitment Status : Unknown
Verified June 2011 by Taipei Medical University WanFang Hospital.
Recruitment status was:  Active, not recruiting
First Posted : June 9, 2011
Last Update Posted : June 9, 2011
Information provided by:

Study Description
Brief Summary:
Cancers are among the most frequent leading causes of death in Taiwan, and many of them show their respective unique epidemiological and pathophysiological features in Taiwanese population. One of the distinguishing features of cancers includes their potential to metastasize outside the primary tumor. Pleural cavity and peritoneum are two of the most frequent sites of metastases when serosal surfaces are involved. The prognoses of such patients are extremely poor with a median survival of months. The understandings of cancer biology of tumor metastasis demand more in-depth studies at the molecular and cell levels. Studies based on cell culture are excellent approaches for this purpose as the cell culture provides a relevant and renewable model for studying the pathological and molecular changes underlying human malignant tumors.

Condition or disease
Metastatic Cancer

Detailed Description:
Due to their easy accessibility, pleural effusions and ascites are two important clinical sources of metastatic cancer cells, which upon isolation, permit comparative studies between the biology nature of primary tumor and metastatic ones. In this study, we will try to isolate cancer cells from human malignant effusions, said to be pleural effusions and/or ascites. We will establish phenotypic alterations along the progression of malignant tumors with serosal metastasis, with special emphasis on expression of some proteases, laminin receptors and transcription factors involved in the process of invasion and metastasis. We would also perform clinical correlations, including tumor type, staging, status of lymph node metastasis and histopathological differentiation and grading, etc.

Study Design

Study Type : Observational
Estimated Enrollment : 20 participants
Official Title: Molecular Profiling of Metastatic Cancer in Pleural Effusion and Ascites
Study Start Date : May 2011
Estimated Study Completion Date : May 2013
Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
cancer patients

Inclusion Criteria:

  • cancer patients
  • pleural effusion or peritoneal effusion

Exclusion Criteria:

  • infected and fever patients
  • anticoagulant treatment patients
  • patients don't attend this study
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01369992

Taipei Medical University - WanFang Hospital
Taipei, Taiwan
Sponsors and Collaborators
Taipei Medical University WanFang Hospital
Principal Investigator: Tze-Sian Chan Taipei Medical University WanFang Hospital
More Information

Responsible Party: Tze-Sian Chan, Department of Gastroenterology
ClinicalTrials.gov Identifier: NCT01369992     History of Changes
Other Study ID Numbers: 99048
First Posted: June 9, 2011    Key Record Dates
Last Update Posted: June 9, 2011
Last Verified: June 2011

Keywords provided by Taipei Medical University WanFang Hospital:
Metastatic Cancer

Additional relevant MeSH terms:
Neoplasm Metastasis
Neoplasms, Second Primary
Pleural Effusion
Neoplastic Processes
Pathologic Processes
Pleural Diseases
Respiratory Tract Diseases