Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response to One-lung Ventilation
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|ClinicalTrials.gov Identifier: NCT01368601|
Recruitment Status : Recruiting
First Posted : June 8, 2011
Last Update Posted : October 18, 2016
|Condition or disease||Intervention/treatment|
|Lung Cancer||Procedure: CPAP (Continuous airway pressure)|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Investigator, Outcomes Assessor)|
|Official Title:||Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response of the Lung With Cancer Undergoing Lobectomy. A Randomised Placebo-controlled Trial|
|Study Start Date :||May 2011|
|Estimated Primary Completion Date :||June 2017|
|Estimated Study Completion Date :||October 2017|
Active Comparator: CPAP (positive airway pressure)
To evaluate if continuous positive airway pressure(CPAP) on the lung undergoing lobectomy can decrease the inflammatory response PPC (postoperative pulmonary complications).
Procedure: CPAP (Continuous airway pressure)
To evaluate if continuous positive airway pressure (CPAP) on the lung undergoing lobectomy can decrease the inflammatory response and PPC.
|No Intervention: Control without CPAP|
- Alveolar and plasmatic cytokines measured before and after atelectasis and re-expansion. [ Time Frame: From preoperative to postoperative (24h) period. ]Alveolar and plasmatic cytokines measured before and after atelectasis and re-expansion.
- Alveolar MICA [ Time Frame: From preoperative to postoperative period (24h) ]Alveolar MICA I (major histocompatibility complex (MHC) class I chain related genes) expression measured at the same control times.
- CT-Scan [ Time Frame: 22-24h after surgery ]Postoperative distribution of well-aerated, non aerated or poorly aerated lung volumes.
- Postoperative pulmonary complications (PPC). [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of 10 days. ]PPC.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01368601
|Hospital del Mar||Recruiting|
|Barcelona, Spain, 08003|
|Contact: Lluis Gallart, PhD 0034 93 2483350 Lgallart@parcdesalutmar.cat|