Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response to One-lung Ventilation
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|ClinicalTrials.gov Identifier: NCT01368601|
Recruitment Status : Recruiting
First Posted : June 8, 2011
Last Update Posted : October 18, 2016
|Condition or disease||Intervention/treatment||Phase|
|Lung Cancer||Procedure: CPAP (Continuous airway pressure)||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Investigator, Outcomes Assessor)|
|Official Title:||Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response of the Lung With Cancer Undergoing Lobectomy. A Randomised Placebo-controlled Trial|
|Study Start Date :||May 2011|
|Estimated Primary Completion Date :||June 2017|
|Estimated Study Completion Date :||October 2017|
Active Comparator: CPAP (positive airway pressure)
To evaluate if continuous positive airway pressure(CPAP) on the lung undergoing lobectomy can decrease the inflammatory response PPC (postoperative pulmonary complications).
Procedure: CPAP (Continuous airway pressure)
To evaluate if continuous positive airway pressure (CPAP) on the lung undergoing lobectomy can decrease the inflammatory response and PPC.
|No Intervention: Control without CPAP|
- Alveolar and plasmatic cytokines measured before and after atelectasis and re-expansion. [ Time Frame: From preoperative to postoperative (24h) period. ]Alveolar and plasmatic cytokines measured before and after atelectasis and re-expansion.
- Alveolar MICA [ Time Frame: From preoperative to postoperative period (24h) ]Alveolar MICA I (major histocompatibility complex (MHC) class I chain related genes) expression measured at the same control times.
- CT-Scan [ Time Frame: 22-24h after surgery ]Postoperative distribution of well-aerated, non aerated or poorly aerated lung volumes.
- Postoperative pulmonary complications (PPC). [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of 10 days. ]PPC.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01368601
|Hospital del Mar||Recruiting|
|Barcelona, Spain, 08003|
|Contact: Lluis Gallart, PhD 0034 93 2483350 Lgallart@parcdesalutmar.cat|